结核丸联合抗结核药物治疗反复难治性结核病的临床疗效观察  

Observation on Clinical Effects of Tuberculosis Pills Combined with Antituberculosis Drugs in the Treatment of Recurrent Refractory Tuberculosis

作　　者：何琼[1] 高晓东[1] 李晓琴 黄海涛 李江红[4] 满世军 高佩媛[1] 赵天莹[1] HE Qiong;GAO Xiaodong;LI Xiaoqin;HUANG Haitao;LI Jianghong;MAN Shijun;GAO Peiyuan;ZHAO Tianying(Gansu Provincial Center for Disease Control and Prevention,Lanzhou 730000,China;Liangzhou District Hospital of Infectious Disease of Wuwei;Tianshui Hospital of Infectious Disease;Tianshui Center for Disease Control and Prevention;Wuwei Center for Disease Control and Prevention)

机构地区：[1]甘肃省疾病预防控制中心,甘肃兰州730000 [2]武威凉州区传染病医院 [3]天水市传染病医院 [4]天水市疾病预防控制中心 [5]武威市疾病预防控制中心

出　　处：《西部中医药》2021年第6期110-114,共5页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察结核丸联合化疗治疗反复性、难治性结核病的临床疗效。方法:选择202例确诊的复治涂阳肺结核患者,随机分为观察组和对照组,每组101例。对照组给予单纯抗结核药物治疗,观察组内服抗结核药物联合中药结核丸治疗。观察两组临床疗效、痰检结果、痰涂片转阴率、症状变化及肝功能指标。结果:观察组临床有效率[99.01%(100/101)]优于对照组[92.08%(93/101)](P<0.05)。观察组治疗第8、24周痰检转阴率分别为96.04%(97/101)及100%(101/101);对照组治疗第8、24周痰检转阴率均为99.01%(100/101),两组比较差异无统计学意义(P>0.05)。治疗第4、8、24周后,ALT及AST水平,观察组均较对照组同期降低明显,差异有统计学意义(P<0.05)。结论:结核丸联合化疗治疗反复性、难治性肺结核,可提高临床疗效、痰检转阴率,改善临床症状,且可缓解肝功能损伤。Objective:To observe clinical effects of tuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis.Methods:All 202 patients who were confirmed and retreatment of smear positive pulmonary tuberculosis were selected and randomized into the observation group and the control group,101 cases in each group.The control group accepted only antituberculosis drugs,and the observation group oral antituber culosis drugs and tuberculosis pills.To observe clinical effects,the results of sputum examination,negative conversion rate of sputum smear,the changes of the symptoms and the indexes of liver function between both groups.Results:Clinical effective rate of the observation group was 99.01%(100/101),superior to 92.08%(93/101)of the control group(P<0.05);the results of sputum examination,negative conversion rates of the observation group at the eighth and 24th week of treatment were 96.04%(97/101)and 100%(101/101)respectively,while the rates of the control group at the eighth and 24th week of treatment were 99.01%(100/101)and 99.01%(100/101),and the difference had no statistical meaning between both groups(P>0.05);after four,eight and 24 weeks of treatment,the levels of ALT of the observation group lowered compared with these of the control group,and the difference had statistical meaning(P<0.05);after eight and 24 weeks of treatment,the levels of AST of the observation group reduced compared with the control group,and the difference showed statistical meaning(P<0.05).Conclusion:Tuberculosis pills and chemotherapy in the treatment of recurrent refractory tuberculosis could raise clinical effects and negative conversion rates of sputum examination,improve clinical symptoms and relieve liver function damage.

关 键 词：结核病 反复性 难治性 结核丸 临床疗效 中医药 痰检 

分 类 号：R521[医药卫生—内科学]