程序性死亡受体1/程序性死亡配体在结核分枝杆菌感染免疫中的作用和宿主导向治疗前景  

Immune role of programmed death 1/programmed death-ligand pathway in Mycobacterium tuberculosis infection and prospects for host-directed therapy

作　　者：张丽帆[1,2,3] 杨峥蓉 刘晓清[1,2,3] Zhang Lifan;Yang Zhengrong;Liu Xiaoqing(Division of Infectious Diseases,State Key Laboratory of Complex Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;Clinical Epidemiology Unit,International Epidemiology Network,Peking Union Medical College Hospital,Chinese Academy of Medical Science,Beijing 100730,China;Centre for Tuberculosis Research,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院,北京协和医院,疑难重症及罕见病国家重点实验室,感染内科,北京100730 [2]中国医学科学院北京协和医学院,国际临床流行病学网,临床流行病学教研室,北京100730 [3]中国医学科学院北京协和医学院,结核病研究中心,北京100730

出　　处：《中华实验和临床感染病杂志（电子版）》2021年第3期145-148,共4页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：艾滋病和病毒性肝炎等传染病科技重大专项课题(No.2017ZX10201302);中国医学科学院医学与健康科技创新工程项目(No.2016-I2M-1-013、2019-I2M-2-005);中国医学科学院北京协和医学院中央级公益性科研院所基本科研业务项目(No.2017PT31010)。

摘　　要：程序性死亡受体1(PD-1)/程序性死亡配体(PD-L)信号转导通路作为近年来的研究热点,其对恶性肿瘤的显著疗效为慢性感染性疾病患者的治疗提供了新思路。但应用PD-1抑制剂治疗恶性肿瘤过程中,出现结核分枝杆菌感染再活动的个案报道呈增加趋势。结核病是由结核分枝杆菌(MTB)感染所致,是由单一致病菌致病导致死亡病例最多的疾病,严重危害人们的健康。潜伏性结核分枝杆菌感染(LTBI)是MTB在体内的稽留状态,LTBI在特定条件下可发展为活动性结核病(ATB)。我国在结核病的防控工作方面始终面临着严峻挑战。本文就PD-1/PD-L信号转导通路在MTB感染免疫中的作用进行综述,为深入理解MTB宿主免疫以及探索新的结核病宿主导向治疗(HDT)方案提供线索。The programmed death 1(PD-1)/programmed death-ligand(PD-L)pathway had been a research hotspot in recent years,and its significant clinical benefit in patients with malignant tumors had provided new ideas for the treatment of patients with chronic infectious diseases.Cases of Mycobacteria tuberculosis(MTB)infection reactivity during PD-1 inhibitor treatment of malignant tumors have now been reported in the literature,which have shown a tendency to increase.Tuberculosis,a communicable disease caused by MTB,was a disease which cause the most number of deaths by a single pathogen.Latent MTB infection(LTBI)was pragmatically defined as infection with MTB.Latent tuberculosis infection could progress to active tuberculosis(ATB)under specific conditions.The epidemic situation of tuberculosis has brought severe challenges to the prevention and control of tuberculosis in China.This review discussed the immune role of PD-1/PD-L pathway in MTB infection and provides clues for in-depth understanding of MTB host immunity and exploring new tuberculosis host-directed therapy.

关 键 词：程序性死亡受体1/程序性死亡配体 结核病 潜伏性结核感染 T细胞免疫反应 宿主导向治疗 

分 类 号：R52[医药卫生—内科学]