光滑念珠菌耐药机制及中西药治疗光滑念珠菌感染研究进展  

Research progress on Chinese and western medicine treatment for Candida glabrata infection

作　　者：张冠怡 姚冬婷[1] 王健 胡晓波[1] ZHANG Guanyi;YAO Dongting;WANG Jian;HU Xiaobo(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai Center for Clinical Laboratory,Shanghai 200126,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海市临床检验中心,上海200126

出　　处：《检验医学》2021年第7期761-765,共5页Laboratory Medicine

基　　金：国家自然科学基金青年基金(81803893)。

摘　　要：光滑念珠菌是临床最常见的非白念珠菌,对唑类药物的耐药率逐年增高,为念珠菌病的临床治疗带来一定的困难。光滑念珠菌相关耐药基因研究发现,生物膜相关基因和外排基因等的表达与其耐药密切相关。为解决光滑念珠菌耐药问题,临床采用中西药结合的方法,为光滑念珠菌感染的临床治疗提供了新的途径。文章对光滑念珠菌耐药机制及中西药治疗光滑念珠菌感染的研究进展进行综述,以期为临床治疗光滑念珠菌感染提供参考。Candida glabrata is the most common non-Candida albicans,and its resistance rate to azoles is increasing year by year,which brings certain difficulty for the clinical treatment of candidiasis.Studies on genes related to resistance of Candida glabrata find that biofilm-related genes and efflux genes are closely related to drug resistance.In order to solve the problem of drug resistance,the drug resistance mechanism of Candida glabrata and the combination of traditional Chinese medicine in the modern clinical treatment of Candida glabrata infection provides a approach of therapy for the clinical treatment of Candida glabrata infection.

关 键 词：光滑念珠菌 生物膜 中西药结合 药物外排 耐药基因 

分 类 号：R379.4[医药卫生—病原生物学]