干扰素α-2b栓联合宫颈环形电切术治疗高危型HPV感染的临床疗效  

Efficacy analysis of interferonα-2b combined with circular cervical resection in patients with cervicitis complicated with high-risk HPV infection

作　　者：武丽蕊 王兰朋[2] 李红霞 魏玲 WU Lirui;WANG Lanpeng;LI Hongxia;WEI Ling(Department of Obstetrics and Gynecology,Hebei PETRO China Central Hospital,Langfang,Hebei 065000,China;Langfang People's Hospital,Langfang,Hebei 065000,China)

机构地区：[1]河北中石油中心医院妇科,河北省廊坊市065000 [2]廊坊市人民医院,河北省廊坊市065000

出　　处：《中南医学科学杂志》2021年第4期439-442,共4页Medical Science Journal of Central South China

基　　金：廊坊市科技支撑计划项目(2014013026)。

摘　　要：目的探讨干扰素α-2b栓联合宫颈环形电切术治疗宫颈炎合并高危型人乳头状瘤病毒(HPV)感染的疗效。方法选择宫颈炎合并高危型HPV感染患者164例,均行阴道镜下宫颈活检和液基薄层细胞学检查,随机均分为对照组82例,联合治疗组82例。对照组接受宫颈环形电切术治疗,联合治疗组接受干扰素α-2b栓联合宫颈环形电切术治疗。术后6月,比较两组患者的整体疗效、HPV病毒载量、HPV转阴率和宫颈炎症指标,比较两组宫颈愈合时间、药物相关不良反应的发生情况。结果术后6月,联合治疗组疗效分级、总有效率均优于对照组(P<0.05);联合治疗组HPV病毒载量低于对照组,HPV转阴率均高于对照组(P<0.05)。联合治疗组阴道灌洗液中白细胞介素-2、白细胞介素-10、肿瘤坏死因子-α水平低于对照组(P<0.05)。联合治疗组创面愈合时间、阴道流血时间、排液时间均短于对照组(P<0.05)。两组间阴道局部红肿、干涩、瘙痒等不良反应发生率差异无统计学意义(P>0.05)。结论干扰素α-2b栓治疗能够促进宫颈炎合并高危型HPV感染的术后恢复,提升疗效,且在治疗安全性方面较为可靠。Aim To investigate the effect of interferonα-2 b suppository combined with cervical circular electrotomy in the treatment of cervicitis with high risk human papillomavirus(HPV)infection.Methods 164 patients with cervicitis and high risk HPV infection were randomly divided into control group and combined treatment group.The control group was treated by cervical ring electrosurgery,and the patients in the combined treatment group were treated with interferonα-2 b suppository combined with cervical ring electrosurgery.The overall efficacy,HPV viral load,HPV negative rate and cervicitis index were compared in the two groups at 6 months after operation,and the time of cervical healing and adverse drug-related reactions were compared.Results The curative effect grade and total effective rate of the combined treatment group were better than that of the control group(P<0.05),the viral load of the combined treatment group was lower than that of the control group,and the negative rate of HPV was higher than that of the control group(P<0.05).The levels of IL-2,IL-10,TNF-αin vaginal lavage of the combined treatment group were lower than those in the control group(P<0.05).The healing time,vaginal bleeding time and drainage time of the combined treatment group were shorter than that of the control group(P<0.05).There was no significant difference in the incidence of local red swelling,dryness and pruritus between the two groups(P>0.05).Conclusion Interferonα-2 b suppository can promote the postoperative recovery of cervicitis with high-risk HPV infection,improve the efficacy,and it is reliable in the safety of treatment.

关 键 词：干扰素Α-2B 高危型人乳头状瘤病毒 宫颈炎 宫颈环形电切术 

分 类 号：R711.32[医药卫生—妇产科学]