几种常见天然化合物对ABCA1表达影响的研究进展  

Research progress on the effects of several natural compound on ABCA1

作　　者：廖凌骁 龚朵 周玉生[1] 唐朝克[2] LIAO Lingxiao;GONG Duo;ZHOU Yusheng;TANG Chaoke(Institute of Pharmacy and Pharmacology,University of South China&Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study,Hengyang,Hunan 421001,China;Institute of Cardiovascular Disease,University of South China&Key Laboratory for Arteriosclerology of Hunan Province&Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang,Hunan 421001,China)

机构地区：[1]南华大学药物药理研究所湖南省分子靶标新药研究协同创新中心,湖南省衡阳市421001 [2]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技合作与创新联合实验室,湖南省衡阳市421001

出　　处：《中南医学科学杂志》2021年第4期489-492,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金项目(81770461)。

摘　　要：动脉粥样硬化是心血管疾病的主要病理基础,细胞内胆固醇蓄积引起的泡沫细胞形成是导致动脉粥样硬化发展的重要因素。三磷酸腺苷结合盒运转体A1(ABCA1)在胆固醇代谢中有着重要作用。许多天然化合物如葛根素、姜黄素、芍药醇等能够增加ABCA1的表达,促进胆固醇流出,减少细胞内胆固醇蓄积,抑制泡沫细胞形成。本文主要综述了天然化合物对ABCA1表达调控及动脉粥样硬化的影响,为心血管疾病的预防与治疗提供新的思路。Atherosclerosis is the main reason leading to cardiovascular diseases and foam cell formation is an important factor to promote the development of atherosclerosis.ATP binding cassette A1(ABCA1)plays an important role in cholesterol metabolism and atherosclerosis.Many natural compound,such as puerarin,curcumin,paeonol and so on,can increase ABCA1 expression and cholesterol efflux to inhibit cholesterol accumulation and foam cell formation.This article reviews the effects of natural compound on ABCA1 regulation and atherosclerosis progression to provide the new ideas for the prevention and treatment of cardiovascular diseases.

关 键 词：天然化合物 ABCA1 巨噬细胞 动脉粥样硬化 

分 类 号：R972[医药卫生—药品]