芳氧苯氧丙酰胺类化合物的合成与除草活性  

Synthesis and Herbicidal Activity Research of Aryloxyphenoxypropanamide Compounds

作　　者：梁爽 刘鹏飞 程学明 张孟迪 李斌 杨辉斌 LIANG Shuang;LIU Peng-fei;CHENG Xue-ming;ZHANG Meng-di;LI Bin;YANG Hui-bin(State Key Laboratory of the Discovery and Development of Novel Pesticide,Shenyang Sinochem Agrochemicals R&D Co.,Ltd.,Shenyang 110021,China)

机构地区：[1]沈阳中化农药化工研发有限公司新农药创制与开发国家重点实验室,沈阳110021

出　　处：《农药》2021年第7期475-477,495,共4页Agrochemicals

基　　金：“十三五”国家重点研发计划项目(2016YFD0300708)。

摘　　要：[目的]发现高除草活性化合物。[方法]通过亚结构拼接,设计合成了一系列芳氧苯氧丙酸酰胺类化合物。[结果]生测数据显示,大多数化合物在15 g a.i./hm2剂量下对稗草的防效大于80%,其中化合物1a和1b防效大于95%。[结论]设计合成的化合物均具有较好的活性。构效关系显示,随着氮氧杂环上碳原子个数的增加,活性有降低的趋势。[Aims] This study aims to discover new herbicidal compounds with high activity. [Methods] A series of aryloxyphenoxypropanamide compounds were designed and synthesized by substructural splicing. [Results] Preliminary bioassay indicated that most compounds exhibited more than 80% control against Echinochloa crus-galli at 15 g a.i./ha,and 1 a and 1 b exhibited more than 80% control against E. crus-galli. [Conclusions] The designed compounds all showed good herbicidal activity. The structure-activity relationship indicated that the activity tended to decrease with the increase of the number of carbon atoms in the nitrogen and oxygen heterocycle.

关 键 词：芳氧苯氧丙酸 合成 除草活性 

分 类 号：TQ460.3[化学工程—制药化工]