免疫代谢调控子宫内膜微环境和母-胎免疫耐受的研究进展  

Advances on the immunometabolism in regulating the endometrial microenvironment and maternal-fetal tolerance

作　　者：刁梁辉 蔡松辰 刘苏 黄春宇 李龙飞 李玉叶 曾勇 Diao Lianghui;Cai Songchen;Liu Su;Huang Chunyu;Li Longfei;Li Yuye;Zeng Yong(Shenzhen Key Laboratory for Reproductive Immunology of Peri-implantation,Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics,Clinical Research Center for Reproductive Medicine,Shenzhen Zhongshan Urology Hospital,Shenzhen 518045,China)

机构地区：[1]深圳市围着床期生殖免疫重点实验室,深圳中山生殖与遗传研究所,深圳中山泌尿外科医院生殖医学临床研究中心,518045

出　　处：《中华生殖与避孕杂志》2021年第5期448-455,共8页Chinese Journal of Reproduction and Contraception

基　　金：国家重点研发计划(2018YFC1003900/2018YFC1003904);国家自然科学基金青年项目(81701529);深圳市医疗卫生三名工程项目(SZSM201502035);深圳市自然科学基金面上项目(JCYJ20190813161801676)。

摘　　要：子宫内膜微环境和妊娠免疫调控是近年来生殖免疫研究的重点和难点。在妊娠建立过程中,免疫细胞通过适应性重塑,以协助构建胎儿友好的免疫微环境,使胚胎获得“免疫豁免”。免疫代谢作为近十年快速发展的新兴研究领域,重点关注免疫和代谢的相互作用及其在生理病理中的机制。但是目前对于免疫代谢如何参与调控子宫内膜微环境和母-胎免疫耐受的报道还相对不足。本文从肿瘤微免疫代谢对妊娠免疫代谢的启示出发,综述了免疫细胞分化和功能的代谢通路在母-胎耐受微环境塑造中的潜在调控作用,分析代谢和营养异常与妊娠疾病的关系,并从临床应用角度探讨了代谢抑制剂和饮食干预对改善妊娠结局的可能性。The endometrial microenvironment and the immune regulation of pregnancy is a recent focus and challenge in the field of reproductive immunology.During the establishment of pregnancy,the immune cells assist in shaping a fetus-friendly immune microenvironment through adaptive reprogramming,thereby allowing the embryo to obtain"immune privilege".Immunometabolism is an emerging research field that has been developing rapidly in the last decade,focusing on the interaction between the immunology and metabolism and their roles in the physiopathology.However,the current evidence regarding how immunometabolism is involved in the regulation of the endometrial microenvironment and maternal-fetal immune tolerance is insufficient.In light of the implications of tumor immunometabolism for immunometabolism in pregnancy,the metabolic pathways of immune cell differentiation and function are reviewed for their potential regulatory role in shaping the maternal-fetal tolerance microenvironment.The relationship between metabolic and nutritional abnormalities and pregnancy disorders is analyzed.Finally,the possibility of improving pregnancy outcomes through immunometabolic inhibitors or dietary interventions is explored from a clinical application perspective.

关 键 词：免疫调节 代谢 子宫内膜 细胞微环境 胚胎种植 免疫耐受 妊娠免疫 

分 类 号：R392.6[医药卫生—免疫学]