垂体后叶注射液联合卡前列素氨丁三醇在产后出血防治中的效果观察  

Efficacy of posterior pituitary injection combined with carboprost tromethamine in prevention and treatment of patients with postpartum hemorrhage

作　　者：李妞 LI Niu(Dept,of Obstetrics,the 1^(st)Affiliated Hospital of Henan University of Science&Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院产科,河南洛阳471000

出　　处：《华夏医学》2021年第3期88-92,共5页Acta Medicinae Sinica

基　　金：2019年度洛阳市医疗卫生科技计划项目(1920001A)。

摘　　要：目的:探讨垂体后叶注射液联合卡前列素氨丁三醇在产后出血防治中的效果。方法:选取顺产分娩的62例产妇作为研究对象,按照随机数字表法分为对照组和观察组,每组各31例。对照组采用卡前列素氨丁三醇治疗,观察组采用卡前列素氨丁三醇联合垂体后叶注射液治疗。对比两组产后2 h和产后24 h时出血量;用药前和用药后24 h时的子宫平滑肌收缩功能(频率、幅度、活动力);记录对比两组不良反应发生情况。结果:观察组产后2 h和产后24 h出血量均少于对照组(P<0.05);用药后24 h,两组子宫平滑肌收缩频率、幅度、活动力均高于用药前,且观察组高于对照组,两组比较差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:垂体后叶注射液联合卡前列素氨丁三醇在产后出血防治中的应用效果较好,可减少产妇出血量,改善子宫平滑肌收缩功能,且安全性较好。Objective: To investigate the efficacy of posterior pituitary injection combined with carboprost tromethamine in the prevention and treatment of postpartum hemorrhage. Methods: 62 cases of parturients who delivered naturally were randomized into the control group and observation group, with 31 cases in each group. The control group were treated with carboprost tromethamine, while the observation group were treated with carboprost tromethamine combined with posterior pituitary injection. The amount of bleeding 2 hours and 24 hours after delivery, the contractile function of uterine smooth muscle(frequency, amplitude and activity)before and 24 hours after medication were compared between the two groups;and the adverse reactions were recorded and compared between the two groups. Results: The amount of bleeding 2 hours and 24 hours after delivery in the observation group was less than that in the control group, with a statistical difference(P<0.05);24 hours after medication, the contraction frequency, amplitude and activity of uterine smooth muscle in both groups were higher than those before medication, and the observation group’s was higher than that of the control group, with significant differences(P<0.05);and there was no significant difference in the incidence of adverse reactions in both groups(P>0.05). Conclusion: Posterior pituitary injection combined with carboprost tromethamine has a good application effect in the prevention and treatment of patients with postpartum hemorrhage, which can reduce the amount of maternal bleeding and improve the uterine smooth muscle contraction function, which is of safety.

关 键 词：产后出血 垂体后叶注射液 卡前列素氨丁三醇 

分 类 号：R714.461[医药卫生—妇产科学]