胰岛素样生长因子-1对内耳保护机制的研究进展  

Research progress on the protective mechanism of insulin like growth factor-1 on inner ear

作　　者：吴婷 徐聪[2] 孙岩[1] WU Ting;XU Cong;SUN Yan

机构地区：[1]青岛大学附属烟台毓璜顶医院耳鼻咽喉头颈外科,山东烟台264000 [2]滨州医学院

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第6期572-576,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：感音神经性聋(sensorineural hearing loss, SNHL)是造成听力损伤的主要发病类型。在我国,每年有5/100 000~27/100 000因SNHL导致听力减退或听力丧失,在美国每年约有6.6万的SNHL新发病例[1]。As one of the neurotrophic factors and insulin family, insulin like growth factor-1(IGF-1) can promote cell synthesis and metabolism in tissues and organs, activate cell growth, proliferation and differentiation, and inhibit cell apoptosis. Sensorineural hearing loss is the most common manifestation of the inner ear disease, which is mainly caused by the damage of cochlear hair cells. The lack of IGF-1 directly affects the growth, development and differentiation of cochlear hair cells, thus IGF-1 participates in the maintenance of cell survival and repair during inner ear cell injury. This article systematically reviews the recent research progress on the protective mechanism of IGF-1 on the inner ear.

关 键 词：胰岛素样生长因子-1 毛细胞 螺旋神经节 感音神经性聋 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]