脑出血后病理生理机制的研究进展  

An update on pathophysiological mechanisms of intracerebral hemorrhage

作　　者：陈勇安 梁洪生[1] 王森[1] 方晓丰 朱国旭 荣毅伟 张相彤[1] CHEN Yong-an;LIANG Hong-sheng;WANG Sen;FANG Xiao-feng;ZHU Guo-xu;RONG Yi-wei;ZHANG Xiang-tong(Department of Neurosurgery,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,China)

机构地区：[1]哈尔滨医科大学第一附属医院神经外科,黑龙江哈尔滨150001

出　　处：《解剖科学进展》2021年第3期381-384,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81571108/81501050);哈尔滨市科技创新人才研究专项资金项目(2017RAXXJ042)。

摘　　要：脑出血(intracerebral hemorrhage, ICH)是一类严重的脑卒中,其高的致残率、致死率极大地威胁人类健康。脑出血后脑损伤的机制十分复杂,根据其发生的特点,分为原发性脑损伤和继发性脑损伤,其中继发性脑损伤,如炎症、氧化应激、铁的细胞毒性、凝血酶等,在脑出血预后占据着非常重要的作用。进一步明确脑出血后脑损伤的具体病理生理机制,有利于寻找到新的治疗靶点,开发新的药物。Intracerebral hemorrhage(ICH) is a kind of severe cerebral apoplexy, with a high rate of disability and mortality, and poses a great threat to human health. The mechanism of brain injury after intracerebral hemorrhage is very complex. According to its characteristics, it can be divided into primary brain injury and secondary brain injury. Secondary brain injury, such as inflammation, oxidative stress, iron cytotoxicity and thrombin, plays an important role in the prognosis of intracerebral hemorrhage. To further clarify the specific pathophysiological mechanism of brain injury after intracerebral hemorrhage is conducive to finding new therapeutic targets and developing new drugs.

关 键 词：病理生理机制 继发性脑损伤 原发性脑损伤 氧化应激 细胞毒性 HEMORRHAGE 脑出血后 凝血酶 

分 类 号：R651.1[医药卫生—外科学]