脐血造血干细胞移植的临床研究进展  

Advances on clinical study of cord blood stem cell transplantation

作　　者：徐世侠 唐湘凤 XU Shixia;TANG Xiangfeng(Department of Pediatrics,Beijing Eden Hospital,Beijing 100097,China;Department of Pediatrics,the Sixth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]北京怡德医院儿科,北京100097 [2]中国人民解放军总医院第六医学中心儿科,北京100048

出　　处：《医学研究与教育》2021年第3期1-6,共6页Medical Research and Education

基　　金：首都临床特色应用研究专项(Z181100001718032)。

摘　　要：脐血已逐渐成为异基因造血干细胞移植治疗中的一个重要的干细胞来源。尽管移植后感染相关病死率稍高,但由于脐血容易获得、移植后移植物抗宿主病的发生率低等优点,脐血移植患者的存活率与其他类型的造血干细胞移植相当。脐血移植技术的不断改善也给患者带来了较好的疗效,脐血的临床应用为多种难治性疾病的治疗提供了新的方法。现就近年来脐血移植的改进措施、脐血的选择及脐血在其他疾病的应用进行综述。Umbilical cord blood has gradually become an important source of stem cells in allogeneic stem cell transplantation.Although the post-transplantation infective fatality rate is higher,the survival rate of cord blood transplantation is comparable to other types of stem cell transplantation due to the advantages of easy access and lower incidence of GVHD(graft-versus-host diseases,GVHD).The improvement of cord blood transplantation technology has also brought better curative effect to the patients.The clinical application of umbilical cord blood provides a new method for the treatment of many refractory diseases.This article reviews the improvement of cord blood transplantation in recent years,the selection of cord blood for transplantation and the application of umbilical cord blood in other related diseases.

关 键 词：脐血 干细胞移植 移植物抗宿主病 细胞治疗 

分 类 号：R55[医药卫生—血液循环系统疾病]