雾化吸入硝酸甘油与西地那非治疗新生儿持续性肺动脉高压疗效比较  

Comparison of efficacy of atomized inhalation of nitroglycerin and sildenafil in the treatment of persis-tent pulmonary hypertension of newborn

作　　者：李红亚[1] 李斌[2] 张丛敏[1] 崔海敏 吕园园 LI Hongya;LI Bin;ZHANG Congmin;CUI Haimin;LYU Yuanyuan(Department of Neonatology,Baoding No.1 Central Hospital,Baoding 071000,China;Department of Neonatology,Maternal and Child Care Service Centre of Baoding,Baoding 071000,China)

机构地区：[1]保定市第一中心医院新生儿科,河北保定071000 [2]保定市妇幼保健院新生儿科,河北保定071000

出　　处：《医学研究与教育》2021年第3期29-33,共5页Medical Research and Education

摘　　要：目的探讨雾化吸入硝酸甘油与西地那非治疗新生儿持续性肺动脉高压的疗效差异。方法将54例持续性肺动脉高压新生患儿按数字随机表法分为硝酸甘油组(n=27)与西地那非组(n=27),2组患儿均接受氧气吸入、纠正酸中毒、维持电解质平衡等治疗。在上述治疗基础上,硝酸甘油组应用雾化吸入硝酸甘油,西地那非组则给以鼻饲或口服西地那非,对比分析2组的疗效及安全性。结果治疗前,2组患儿HR、RR、肺动脉收缩压(systolic pulmonary artery pressure,SPAP)、PaO_(2)相比,差异无统计学意义(P>0.05)。治疗后,硝酸甘油组患儿与西地那非组患儿的HR、RR、SPAP下降显著,PaO_(2)上升显著,2组患儿HR、RR、SPAP、PaO_(2)治疗前后差异有统计学意义(P<0.05),治疗有效。2组患儿的临床治愈率差异无统计学意义(P>0.05)。结论雾化吸入硝酸甘油和鼻饲或口服西地那非治疗轻中度新生儿持续性肺动脉高压均有效,疗效无差别。Objective To investigate the difference in the efficacy of atomized inhalation of nitroglycerin and sildenafil in the treatment of neonatal pulmonary hypertension.Methods All of 54 cases of PPHN were randomly divided into nitroglycerin group(n=27)and sildenafil group(n=27),and all children received general treatments such as oxygen inhalation,acidosis correction,electrolyte balance maintenance and so on.On the basis of the above treatment,the patients of nitroglycerin group were treated with atomized inhalation of nitroglycerin,and those of sildenafil group were given nasal feeding or oral sildenafil.The efficacy and safety after treatment were compared and analyzed.Results Before treatment,there were no significant differences in the heart rate(HR),respiratory rate(RR),systolic pulmonary artery pressure(SPAP)and arterial oxygen partial pressure(PaO_(2))between two groups(P>0.05).After treatment,HR,RR and SPAP in the nitroglycerin group and the sildenafil group decreased significantly,while the index value of PaO_(2) increased significantly.Compared with before treatment,HR,RR,SPAP and PaO_(2) in the two groups showed statistically significant differences(P<0.05),indicating that the treatment was effective.There was no significant difference in the clinical cure rate between the two groups(P>0.05).Conclusion Atomized nitroglycerin inhalation,nasal feeding or oral sil-denafil are both effective in the treatment of neonatal mild to moderate pulmonary hypertension,with strong prac-ticability,good safety,cheap and there was no difference in efficacy,which are ideal schemes for the treatment of this disease.

关 键 词：硝酸甘油 西地那非 新生儿 持续性肺动脉高压 

分 类 号：R72[医药卫生—儿科]