T2WI-FS序列影像组学诊断宫颈癌转移及脉管间隙浸润的价值  

Value of T2WI-FS based radiomics features in the diagnosis of cervical cancer metastasis and lymph vascular space invasion

作　　者：周小玲 赖华 文曦琳 刘春英 ZHOU Xiaoling;LAI Hua*;WEN Xilin;LIU Chunying(Department of Radiology,Women and Children's Hospital Affiliated to School of Medicine,University of Electronic Science and Technology of China,Chengdu Women and Children's Central Hospital,Chengdu 611731,China)

机构地区：[1]电子科技大学医学院附属妇女儿童医院成都市妇女儿童中心医院放射科,成都611731

出　　处：《磁共振成像》2021年第7期69-71,76,共4页Chinese Journal of Magnetic Resonance Imaging

摘　　要：目的研究T2加权脂肪抑制序列(T2-weighted imaging fat suppression,T2WI-FS)影像组学诊断宫颈癌(cervical cancer,CC)淋巴转移及脉管间隙浸润(lymph vascular space invasion,LVSI)的价值。材料与方法回顾性分析2017年6月至2020年6月间66例CC患者临床资料及术前磁共振成像横轴位T2WI-FS图像,勾画病灶感兴趣区域(region of interest,ROI),将患者预处理图像与ROI图像依次导入A.K.软件,提取T2WI-FS图像上病灶组学特征,经特征降维处理后,建立逻辑回归模型影像组学标签,绘制受试者工作特征(receiver operating characteristic,ROC)曲线,分析T2WI-FS组学标签在诊断CC淋巴转移及LVSI中的价值。结果病理检查结果提示存在淋巴转移者共22例,无转移者44例,分析发现,淋巴转移与患者宫颈间质浸润深度及LVSI有关(P值均<0.01);LVSI阳性患者共27例,阴性患者39例,分析发现,LVSI与患者组织分化程度、宫颈间质浸润深度及淋巴结转移有关(P值均<0.01);T2WI-FS影像组学标签评估患者淋巴转移的曲线下面积(area under the area under the curve,AUC)=0.857,诊断敏感度(sensitivity,Sen)=85.0%,特异度(specificity,Spe)=86.7%,评估患者LVSI的AUC=0.807,诊断Sen=68.3%,Spe=88.3%。结论淋巴结转移及LVSI间相互影响,两者均受到宫颈间质浸润深度的影响,T2WI-FS影像组学标签在评估患者淋巴转移及LVSI中均具有较高的效能,在宫颈癌患者术前病情评估,指导手术治疗方案及预后预测中均具有较高的应用价值。Objective:To investigate the value of fat-suppression T2-weighted imaging(T2WI-FS)based radiomics features in the diagnosis of cervical cancer(CC)metastasis and lymph vascular space invasion(LVSI).Materials and Methods:The clinical data and image data of 66 CC patients in our hospital from June 2017 to June 2020 were retrospectively analyzed.Preoperative magnetic resonance imaging(MRI)horizontal position T2WI-FS images delineated the region of interest(ROI).Preprocessing image and ROI image were processed using A.K.software.A total of 402 radiomics features were extracted from T2WI-FS images.ANOVA+MW combined with LASSO methods were used to perform dimensionality reduction.Receiver operating characteristic(ROC)curve was used to value of T2WI-FS based radiomics features in the diagnosis of cervical cancer lymphatic metastasis and LVSI.Results:The pathological examination showed that there were 22 cases with lymphatic metastasis and 44 cases without metastasis.The analysis found that lymphatic metastasis was related to the depth of cervical interstitial infiltration and LVSI(all P<0.01).There were 27 LVSI positive patients and 39 negative patients.Analysis found that LVSI was related to the degree of tissue differentiation,the depth of cervical interstitial infiltration and lymph node metastasis(all P<0.01).The area under the curve(AUC),sensitivity(Sen)and specificity(Spe)of T2WI-FS imaging radiomics features in the diagnosis of lymphatic metastasis were 0.857,85.0%,and 86.7%,respectively,and those in the diagnosis of LVSI were 0.807,68.3%and 88.3%,respectively.Conclusions:Both lymph node metastasis and LVSI are affected by the depth of cervical stromal invasion.T2WI-FS imaging has high efficiency in evaluating lymph node metastasis and LVSI.The preoperative examination is of great significance in guiding surgical treatment and predicting prognosis of cervical cancer patients.

关 键 词：T2加权脂肪抑制序列 影像组学 宫颈癌 淋巴转移 脉管间隙浸润 术前诊断价值 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.33[医药卫生—诊断学]