紫杉醇类药物眼部不良反应及其防治研究进展  

Research progress on ocular adverse reactions related to paclitaxels and their prevention and treatment

作　　者：叶亚婷 窦国睿 常天芳 储昭节 Ye Yating;Dou Guorui;Chang Tianfang;Chu Zhaojie(Chinese Materia Medica,College of Life Sciences,Northwestern University,Xi′an 710032,China;Depart-ment of Ophthalmology,Xijing Hospital,Air Force Medical University,Xi′an 710032,China;Department of Ophthalmology,the First Affiliated Hospital of Northwest University(Xi′an First Hospital),Xi′an 710002,China)

机构地区：[1]西北大学生命科学学院中药学专业,西安710032 [2]空军军医大学第一附属医院眼科,西安710032 [3]西北大学附属第一医院(西安市第一医院)眼科,西安710002

出　　处：《药物不良反应杂志》2021年第6期312-316,共5页Adverse Drug Reactions Journal

基　　金：国家自然科学基金(81670863,81970814);陕西省重点研发计划(2021SF⁃335);西安市卫生健康委员会科技项目(2020yb07);白求恩·朗沐中青年眼科科研基金(BJ⁃LM2017002J)。

摘　　要：紫杉醇类药物的眼部不良反应可累及眼表、眼附属器及眼内各组织结构,临床表现多样,如干眼、泪道阻塞、结膜炎、角膜炎、黄斑水肿、视网膜损伤、视神经损伤等,可导致不可逆的视功能损害。眼部不良反应发生机制尚不清楚,紫杉醇导致黄斑水肿可能与其导致视网膜色素上皮细胞和Müller细胞功能障碍有关,其他不良反应可能与紫杉醇的细胞毒性有关。应用紫杉醇类药物前应进行眼科基线检查,用药过程中应密切观察有无眼部新发症状。眼部不良反应可以通过眼科常规检查明确诊断,治疗措施主要是及时调整药物和对症治疗。The ocular adverse reactions of paclitaxels can involve the ocular surface,ocular appendages and intraocular tissue,with various clinical manifestations,such as dry eye,lacrimal duct obstruction,conjunctivitis,keratitis,macular edema,retinal injury,optic nerve injury,etc.,which can lead to irreversible visual impairment.The mechanism of ocular adverse reactions is still unclear.In these adverse reactions,macular edema may be related to the dysfunction of retinal pigment epithelial cells and Müller cells caused by paclitaxel,and others may be related to the cytotoxicity of paclitaxels.Baseline eye examina⁃tion should be performed prior to the use of paclitaxels,and new ocular symptoms should be closely moni⁃tored during the treatment.Ocular adverse reactions can be diagnosed definitively through routine ophthalmic examination.The main treatments are timely adjustment of drugs and symptomatic treatments.

关 键 词：紫杉烷类 眼疾病 药物相关的副作用和不良反应 

分 类 号：R969[医药卫生—药理学]