1例氯吡格雷致严重血小板减少的病例分析  

Analysis of a case of severe thrombocytopenia caused by clopidogrel

作　　者：吉顺莉[1] 张春燕[1] 舒冰 JI Shun-li;ZHANG Chun-yan;SHU Bing(Pharmacy Department,Affiliated Hospital of Nantong University,Nantong 226001,China;Pharmacy Department,the First Affiliated Hospital of USTC,Hefei 230001,China)

机构地区：[1]南通大学附属医院,江苏南通226001 [2]中国科技大学附属第一医院,安徽合肥230001

出　　处：《实用药物与临床》2021年第7期637-640,共4页Practical Pharmacy and Clinical Remedies

基　　金：江苏省药学会-奥赛康医院药学基金(A201818);江苏省药学会-天晴医院药学基金(Q2019162);南通市科技计划项目(MSZ18071);南通市药学会-常州四药医院药学科研基金项目(ntyx1820)。

摘　　要：目的通过对1例氯吡格雷片引起严重血小板减少的病例进行分析,探讨开展药学监护的方法和思路。方法参与1例冠心病患者PCI术后合并血小板减少的治疗方案调整,分析患者出现血小板减少的可能原因。结果临床药师认为患者出现严重血小板减少很可能为氯吡格雷所致,建议停药,同时给予升血小板治疗,患者血小板数量有所回升。结论临床药师在药学监护中应提高职业敏感性,及时发现药物相关性问题,发挥专业优势,改善患者预后,保证患者的用药安全。Objective To explore the methods and ideas of pharmaceutical care through the analysis of a case of severe thrombocytopenia caused by clopidogrel tablets.Methods Through participating in the adjustment of the treatment plan for a patient with coronary heart disease complicated with thrombocytopenia after PCI,the possible causes of thrombocytopenia of the patient was analyzed.Results The clinical pharmacist thought that the severe thrombocytopenia of the patient was probably caused by clopidogrel,so it was suggested that the patient should stop taking the drug and be given the platelet-increasing therapy at the same time.The platelet count of the patient was increased.Conclusion In pharmaceutical care,clinical pharmacists should improve their professional sensitivity to timely find drug-related problems,giving play to their professional advantages to improve the prognosis of patients and ensure the safety of drug use.

关 键 词：氯吡格雷 冠心病 血小板减少 

分 类 号：R969[医药卫生—药理学]