Rapid and efficient wounding for in vivo studies of neuronal dendrite regeneration and degeneration  

作　　者：Jianzhi Zhao Xiaojie Wang Xinan Meng Wei Zou Suhong Xu 

机构地区：[1]Center for Stem Cell and Regenerative Medicine and Department of Cardiology of the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058 China [2]The Fourth Affiliated Hospital,Zhejiang University School of Medicine,Yiwu 322000,China [3]Institute of Translational Medicine,Zhejiang University,Hangzhou 310058,China

出　　处：《Journal of Genetics and Genomics》2021年第2期163-166,共4页遗传学报（英文版）

基　　金：funded by NIH Office of Research Infrastructure Programs(P40 OD010440);the MITANI Lab through the National Bio-Resource Project of the MEXT,Japan;supported by the National Natural Science Foundation of China grants(91754111,31972891,and 31671522)to S.X.and(31800861,31970919)to W.Z。

摘　　要：Dendrite growth and branching occur mainly during the developmental stage,and their spatial and temporal wiring is highly linked to the proper functioning of neuronal networks(Jan and Jan,2003).Although it is well known that neuronal dendrites are easily damaged during traumatic brain injury,stroke,and seizure,very little is known about how neurons respond to dendrite injury and initiate regeneration(Liu and Jan,2020).Thus,understanding the cellular and molecular mechanisms of dendrite regeneration and maintenance after injury holds the key to develop novel treatments for human brain damage.

关 键 词：holds branching damage 

分 类 号：R338[医药卫生—人体生理学]