血清胆红素水平在深静脉血栓形成中的临床意义  

Clinical significance of serum bilirubin level in deep vein thrombosis

作　　者：车星[1] 戴翔[1] 李才营[1] 赵英海 Che Xing;Dai Xiang;Li Caiying;Zhao Yinghai(Department of Vascular Surgery,Taizhou People’s Hospital,Taizhou,Jiangsu 225300,China)

机构地区：[1]泰州市人民医院血管外科,江苏泰州225300

出　　处：《中华生物医学工程杂志》2021年第2期194-197,共4页Chinese Journal of Biomedical Engineering

摘　　要：探讨血清胆红素水平在深静脉血栓形成(DVT)中的临床意义。研究发现DVT组的总胆红素(TBIL)和直接胆红素(DBIL)水平显著低于对照组(P<0.05);TBIL与血清C反应蛋白(CRP)、血浆D-二聚体(DD)以及患肢周径差均呈负相关(P<0.05),而DBIL仅和DD呈负相关(P<0.05)。多因素分析结果显示TBIL是发生DVT的独立危险因素。当TBIL诊断临界值为8.2μmol/L时,诊断DVT的敏感度和特异度分别是:70%和65%。TBIL在DVT患者中明显下降,通过动态监测TBIL对于诊断DVT和判断疾病的严重程度有一定的临床价值。The purpose of this study was to investigate the clinical significance of serum bilirubin level in deep vein thrombosis(DVT).The study found that the levels of total bilirubin(TBIL)and direct bilirubin(DBIL)in the DVT group were significantly lower than those in the control group(P<0.05).The TBIL level was negatively correlated with serum C-reactive protein(CRP),and plasma D-dimer(DD)and the ipsilateral-to-contralateral diameter difference(P<0.05),while the DBIL level was negatively correlated with DD alone(P<0.05).Multivariate analysis showed that TBIL was an independent risk factor for DVT.Using a TBIL cutoff of 8.2μmol/L,the sensitivity and specificity in diagnosing DVT were 70%and 65%,respectively.In conclusion,TBIL is significantly decreased in DVT patients;dynamic monitoring of TBIL offers potential clinical value in diagnosing DVT and assessing disease severity.

关 键 词：深静脉血栓形成 胆红素 C反应蛋白 D-二聚体 

分 类 号：R543.6[医药卫生—心血管疾病]