血清微RNA-222表达与多囊卵巢综合征患者糖脂代谢的相关性  

Correlation between serum microRNA-222and metabolism of glucose and lipid in women with polycystic ovary syndrome

作　　者：贺春燕 黄伟[1] 周锋[1] 王进 He Chunyan;Huang Wei;Zhou Feng;Wang Jin(Department of Endocrinology,Puren Hospital Affiliated of Wuhan University of Science and Technology,Wuhan 430081,China)

机构地区：[1]武汉科技大学附属普仁医院内分泌科,430081

出　　处：《中国医师进修杂志》2021年第6期533-537,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨血清微RNA-222(miR-222)表达与多囊卵巢综合征(PCOS)患者糖脂代谢的相关性。方法收集2018年7月至2020年7月在武汉科技大学附属普仁医院接受治疗的100例PCOS患者(PCOS组),选取同期因输卵管因素不孕的85例患者作为对照组。比较两组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、空腹血糖(FPG)、胰岛素抵抗指数(HOMA-IR)水平及血清miR-222表达情况,分析血清miR-222表达与糖脂代谢指标的相关性。结果PCOS组TC、TG、LDL-C、FPG、FINS、HOMA-IR、miR-222水平高于对照组[(1.30±0.25)mmol/L比(1.04±0.21)mmol/L、(4.36±0.91)mmol/L比(3.67±0.61)mmol/L、(2.51±0.89)mmol/L比(2.13±0.42)mmol/L、(5.34±1.56)mmol/L比(4.91±0.84)mmol/L、(11.08±3.83)mU/L比(7.49±2.53)mU/L],HDL-C水平低于对照组[(1.08±0.47)mmol/L比(1.53±0.50)mmol/L],差异均有统计学意义(P<0.05);Logistic回归分析结果表明TC、TG、HDL-C、LDL-C、FINS、HOMA-IR、miR-222是影响PCOS患者糖脂代谢异常的独立危险因素(P<0.05);相关分析表明,PCOS患者血清miR-222表达与TC、TG、HDL-C、LDL-C、FINS、HOMA-IR水平呈正相关(r=0.760、0.737、0.769、0.749、0.825,P<0.05),与HDL-C水平呈负相关(r=-0.743,P<0.05)。结论PCOS患者血清miR-222表达异常升高,与糖脂代谢指标关系密切,可作为糖脂代谢的生物标志物之一。Objective To investigate the relationship between serum microRNA-222(miR-222)and metabolism of glucose and lipid in women with polycystic ovary syndrome(PCOS).Methods A total of 100 patients with PCOS(PCOS group)were enrolled from July 2018 to July 2020 in Puren Hospital Affiliated of Wuhan University of Science and Technology,and another 85 sterility patients were selected as control group.The levels of total cholesterol(TC),triglycerides(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein(LDL-C),fasting insulin(FINS),fasting plasma glucose(FPG),insulin resistance index(HOMA-IR)as well as serum miR-222 were compared between two groups,and the correlation between serum miR-222 and metabolism of glucose and lipid was analyzed.Results The levels of TC,TG,LDL-C,FPG,FINS,HOMA-IR,miR-222 in PCOS group were higher than those in the control group:(1.30±0.25)mmol/L vs.(1.04±0.21)mmol/L,(4.36±0.91)mmol/L vs.(3.67±0.61)mmol/L,(2.51±0.89)mmol/L vs.(2.13±0.42)mmol/L,(5.34±1.56)mmol/L vs.(4.91±0.84)mmol/L,(11.08±3.83)mU/L vs.(7.49±2.53)mU/L;the level of HDL-C in PCOS group was lower than that in the control group:(1.08±0.47)mmol/L vs.(1.53±0.50)mmol/L,and the differences were statistically significant(P<0.05).The results from Logistic regression analysis showed that the levels of TC,TG,HDL-C,LDL-C,FINS,HOMA-IR,miR-222 were independent risk factors for abnormal of metabolism of glucose and lipid of polycystic ovary syndrome patients(P<0.05).The correlation analysis showed that miR-222 expression had positive correlation with TC,TG,LDL-C,FINS,HOMA-IR(r=0.760,0.737,0.769,0.749,0.825,P<0.05),and had negative correlation with HDL-C(r=-0.743,P<0.05).Conclusions The serum miR-222 shows abnormal increase in the PCOS patients,and is closely related to glucose and lipid metabolism.It can be used as a biomarker of abnormal glucose and lipid metabolism.

关 键 词：多囊卵巢综合征 微RNA-222 糖脂代谢 

分 类 号：R711.75[医药卫生—妇产科学]