放创复合伤靶向治疗研究进展  

The mechanism-oriented method to promote the healing of combined radiation and wound injury

作　　者：王碧舟 王珏 孙琪[1] 杨楠[1] 王倩 刘定坤 刘志辉[1] WANG Bi-zhou;WANG Jue;SUN Qi;YANG Nan;WANG Qian;LIU Ding-kun;LIU Zhi-hui(Department of Prosthodontics,Hospital of Stomatology,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院口腔修复科,吉林长春132021

出　　处：《生物技术》2021年第3期306-311,266,共7页Biotechnology

基　　金：吉林省科技厅发展计划项目(20190304032YY);吉林大学研究生创新研究计划项目(101832020CX310)。

摘　　要：放射损伤合并创伤称为"放创复合伤",此类伤口在临床上常见于手术切除原发灶后合并放射治疗的癌症患者。因受放射损伤及创伤的双重影响,此类伤口经久不愈是最为突出的治疗难题。该文着重介绍了细胞因子治疗、干细胞治疗、物理治疗、中药治疗等现有治疗方法,并以放创复合伤难愈机制为导向,具体分析了治疗方法的靶向作用与机制,并对靶向治疗方法现存的临床应用问题进行了讨论与展望,旨在为今后放创复合伤靶向治疗的研究提供新思路。Combined radiation and wound injury(CRWI)is a type of wound that is mainly seen in cancer patients who have received surgical resection of the primary lesion combined with radiotherapy.Affected by both the trauma and radiation,such wounds are relatively difficult to treat,and refractory wound healing is the most prominent challenge.This article focuses on the mechanism of refractory wound healing and introduces the new progress in the application of various biological therapies such as cytokine therapy,stem cell therapy,physical therapy and Chinese medicine treatment.In addition,the existing clinical application problems of targeted therapy were discussed and prospected,aiming to provide new ideas for the future research of targeted therapy for combined radiation and wound injury.

关 键 词：放创复合伤 创面难愈机理 促愈方法 靶向治疗 

分 类 号：R142[医药卫生—公共卫生与预防医学] R641