1型糖尿病治疗研究进展  

Update on the treatment of type 1 diabetes

作　　者：秦福建 曹荣月[1] 金亮[1] QIN Fujian;CAO Rongyue;JIN Liang(School of Life Science and Technology,China Pharmaceutical University,Nanjingl 10038,China)

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210038

出　　处：《沈阳药科大学学报》2021年第6期643-648,共6页Journal of Shenyang Pharmaceutical University

基　　金：国家自然科学基金面上项目(31270985)。

摘　　要：目的通过综述目前新兴的1型糖尿病(T1DM)疗法,为T1DM的临床治疗提供参考。方法利用GeenMedical及知网等检索平台,查阅相关文献42篇,总结近年来T1DM治疗方法的最新进展。结果近年来出现的钠-葡萄糖协同转运蛋白抑制剂(sodium-glucose cotransporters inhibitor,SGLTi)、二甲双胍、抗CD3单克隆抗体、闭环胰岛素泵系统、胰岛移植及干细胞治疗等新兴疗法在T1DM的临床前或临床应用中均显示良好的治疗效果。而肠道菌群和胰岛干细胞为人类防治T1DM提供了新的方向。结论除传统胰岛素治疗外,新型治疗方法对未来T1DM的治疗具有重大意义。Objective To review current emerging therapies for type 1 diabetes(T1 DM)and provide a reference for clinical treatment of T1 DM.Methods Using GeenMedical and cnki.net search platforms,42 related literatures were reviewed,and the latest progress of T1 DM treatment methods was summarized in recent years.Results In recent years,the emerging therapies,such as sodium-glucose cotransporters inhibitor(SGLTi),metformin,anti-CD3 monoclonal antibody,closed-loop insulin pump system,islet transplantation and stem cell therapy have shown very good therapeutic effects in the preclinical or clinical applications of T1 DM.Moreover,the intestinal microflora and islet stem cells provide a new direction for humans to prevent and treat T1 DM.Conclusion In addition to traditional insulin therapy,new treatment methods are of great significance for the future treatment of T1 DM.

关 键 词：1型糖尿病 SGLT抑制剂 抗CD3抗体 二甲双胍 闭环胰岛素泵系统 胰岛移植 干细胞 肠道菌群 

分 类 号：R96[医药卫生—药理学]