右美托咪定和咪达唑仑镇静对行椎管内麻醉的老年患者术后认知功能影响的meta分析  

Meta Anasis of Efficience with Dexmedetomidine and Midazolam on Postoperative Cognitive Function in Elderly Patients Undergoing Spinal Anesthesia

作　　者：黄雅蓓 彭明清[1] HUANG Ya-bei;PENG Ming-qing(The Yongchuan Hospital of Chongqing Medical University,Chongqing 610041,China)

机构地区：[1]重庆医科大学附属永川医院麻醉科,重庆610041

出　　处：《医学食疗与健康》2021年第16期11-11,17,共2页Medical Diet and Health

摘　　要：目的:系统评价右美托咪定和咪达唑仑镇静对行椎管内麻醉的老年患者术后认知功能的影响。方法:检索时限均从2005年1月1日至2017年1月1日。由2位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果:共纳入9个研究,518例患者。Meta分析结果显示:右美托咪定组在术后第1天、第3天、第5天、第7天的MMSE评分均高于咪达唑仑组,差异有统计学意义。结论:现有证据表明,右美托咪定比咪达唑仑在术后认知能力的影响方面影响低,它比咪达唑仑更加合适搭配椎管内麻醉。上述结论尚需开展更多高质量研究予以验证。Objective:To evaluate the effects of dexmedetomidine and midazolam on postoperative cognitive function in elderly patients undergoing spinal anesthesia.Methods:Retrieval time from January 1,2005 to January 1,2017,then independently screened the literature,extracted data and assessed the risk of bias in the study by 2 reviewers,and then used RevMan5.3 software for meta analysis.Results:A total of 518 patients were included in 9 studies.The results of Meta analysis showed that the MMSE scores of dexmedetomidine group on day 1,day 3,day 5 and day 7 were higher than those of midazolam group.Conclusion:Existing evidence showed,The effect of dexmedetomidine and midazolam on postoperative cognitive ability was low,is more suitable for spinal anesthesia than Midazolam.The above conclusions need to be verified by more high-quality studies.

关 键 词：右美托咪定 咪达唑仑 META分析 椎管内麻醉 

分 类 号：R614[医药卫生—麻醉学]