三维胸腔肺通气电阻抗动态仿真方法研究  

Lung ventilation electrical impedance dynamic simulation method based on 3D thoracic model

作　　者：曲振豪 杜强[1] 柯丽[1] 贾静 QU Zhen-hao;DU Qiang;KE Li;JIA Jing(School of Electrical Engineering,Shenyang University of Technology,Shenyang 110870,China;College of Electrical Engineering,Yingkou Institute of Technology,Yingkou 115014,Liaoning Province,China)

机构地区：[1]沈阳工业大学电气工程学院,沈阳110870 [2]营口理工学院电气工程学院,辽宁营口115014

出　　处：《医疗卫生装备》2021年第7期1-7,共7页Chinese Medical Equipment Journal

基　　金：国家自然科学基金项目(52077143);辽宁省自然科学基金计划项目(2019-ZD-0204);辽宁省教育厅重点攻关项目(LZGD2020002)

摘　　要：目的:通过对肺通气时胸部体表电势变化情况进行定量仿真研究,为胸部电阻抗成像和肺生理病理临床监测提供依据。方法:首先结合肺部X射线片以及真实人体肺部生理结构建立包含肺部的三维胸腔模型,同时引入肺组织空气填充系数对肺通气量进行定量描述,得到肺内空气量与电导率之间的关系;然后根据二者的关系设置电导率参数模拟肺部从吸气末到呼气末的动态变化过程;最后采用有限元方法对肺通气状态进行三维动态仿真,并对肺内空气体积与胸部体表电势关系进行计算。为验证肺通气动态仿真方法的准确性,设计实验对20名志愿者深呼吸状态下体表电势进行实际测量,并对仿真与实测数据进行相关性分析。结果:肺内空气量增大时,肺内空气体积增加,肺部电导率降低,流经肺组织内的电流线逐渐减少且分布逐渐不均,同时激励电极周围电势明显升高,体表相邻电极间电势差绝对值增大。仿真与实测数据相关系数为0.9454。结论:肺通气动态仿真方法可以准确地模拟肺通气生理变化过程,并得到肺内空气体积与体表电势之间的定量变化关系,为肺通气动态监测打下了基础。Objective To execute a quantitative simulation study of the changes in thoracic body surface electrical potential during lung ventilation to provide references for thoracic electrical impedance imaging and clinical monitoring of lung physiopathology.Methods Firstly,a 3D thoracic cavity model containing the lungs was established with the considerations on the lung X-ray films and physiological structure of real human lungs,while the air filling coefficient of the lung tissue was introduced to quantitatively describe the lung ventilation volume and determine the relationship between the air amount in the lungs and the electrical conductivity,then the dynamic change process of the lungs from the end of inspiration to the end of expiration was simulated by setting the electrical conductivity parameters accordingly,and finally finite element method was used for the 3D dynamic simulation of the lung ventilation state and the calculation of the relationship between the volume of air in the lung and the electrical potential of the thoracic body surface.To verify the accuracy of the dynamic lung ventilation simulation method,some experiments were designed to measure the body surface potential of 20 volunteers under deep breathing conditions,and correlation analysis was performed between the simulated and measured data.Results As the amount of air in the lungs increased,the volume of air in the lungs rose,the electrical conductivity of the lungs decreased,the current lines flowing through the lung tissue gradually declined and became progressively unevenly distributed,while the electrical potential around the excitation electrodes ascended significantly and the absolute value of the potential difference between adjacent electrodes on the body surface went up.The correlation coefficient between the simulated and measured data was 0.9454.Conclusion The lung ventilation dynamic simulation method accurately simulates the physiological change process of lung ventilation and determines the quantitative change relationship betwee

关 键 词：生物电阻抗 肺通气 三维胸腔模型 动态仿真 定量分析 

分 类 号：R318[医药卫生—生物医学工程]