轻度创伤性颅脑损伤患者早期血清激素水平与抑郁情绪相关性研究  

Study on the correlation between serum hormone levels and depression in patients with mild Traumatic Brain Injury

作　　者：韩闯闯 徐峰[2] HAN Chuang-chuang(School of Medicine, Anhui University of Science and Technology, Huainan 232000, China)

机构地区：[1]安徽理工大学医学院,安徽淮南232000 [2]上海交通大学附属第六人民医院南院,上海201499

出　　处：《牡丹江医学院学报》2021年第4期43-45,92,共4页Journal of Mudanjiang Medical University

摘　　要：目的研究轻度创伤性颅脑损伤(mild Traumatic brain injury,mTBI)患者血清中激素水平与发生抑郁情绪的关系。方法收集2019年3月至2019年12月间于上海交通大学附属第六人民医院南院神经外科住院治疗的mTBI患者67例。ELISA方法检测患者入院时血清中激素水平,并在患者出院后6个月采用Zung抑郁自评量表(Self-rating depression scale,SDS)对患者进行抑郁情绪的评定,将SDS评分≥53分的患者纳入抑郁组(19例),其余患者为非抑郁组(48例)。采用二分类logistic回归分析方法分析mTBI患者抑郁情绪发生的危险因素。结果抑郁组患者出院后6个月SDS评分明显高于非抑郁组(P<0.05);抑郁组血清促肾上腺皮质激素(Adrenocorticotropic hormone,ACTH)水平及促肾上腺皮质激素释放激素(Corticotropin releasing hormone,CRH)高于非抑郁组(P<0.05)。抑郁组患者ACTH水平与SDS评分呈正相关(P<0.05);二元logistic回归分析结果显示,高血清ACTH水平的mTBI患者易出现抑郁情绪[OR=1.090,95%CI(1.027,1.156),P=0.004]。结论mTBI患者血清ACTH及CRH水平升高与抑郁情绪的发生相关,血清ACTH异常是患者后期出现抑郁情绪的危险因素。Objective To investigate the relationship between serum hormone levels and depression of mild traumatic brain injury patients.Methods The clinical data of 67 patients with mTBI from March 2019 to December 2019 in Shanghai Jiaotong University Affiliated Sixth People’s Hospital South Campus were collected.ELISA assay was used to detect the serum hormone levels of patients and the patients were followed up for 6 months.The self-rating depression scale(SDS)was used to evaluate the depression of patients.It included patients with SDS score≥53 in the depression group(19 cases),and the remaining patients were non-depressed(48 cases).The serum levels of various hormones in the two groups were compared.The binary logistic regression analysis method was used to analyze the risk factors of depression in mTBI patients.Results The SDS score was significantly higher than that of the non-depressive group(P<0.05).Besides,compared with the non-depressive group,the serum adrenocorticotropic hormone(ACTH)levels and the corticotropin-releasing hormone(CRH)were apparently higher(P<0.05).Someone positively correlated ACTH levels with SDS scores in patients in the depressive group(P<0.05).Patients with mTBI with high serum ACTH levels were susceptible to depression[OR=1.090,95%CI(1.027,1.156),P=0.004].Conclusion Increased serum ACTH and CRH levels in mTBI patients were associated with the occurrence of depression,and abnormal serum ACTH levels were risk factors for depression.

关 键 词：轻度创伤性颅脑损伤 促肾上腺皮质激素 抑郁 

分 类 号：R651[医药卫生—外科学]