康眠颗粒三种制粒工艺的比较  

Comparison of Three Granulation Technology of Kangmian Granules

作　　者：钱俊[1] 刘佳妮 彭晓莉 张璐瑶 赵琰玲 Qian Jun;Liu Jia-ni;Peng Xiao-li;Zhang Lu-yao;Zhao Yan-ling

机构地区：[1]江苏食品药品职业技术学院,江苏淮安223003

出　　处：《化工设计通讯》2021年第7期57-58,共2页Chemical Engineering Design Communications

基　　金：江苏省高校大学生创新创业训练计划项目(20200604)。

摘　　要：比较康眠颗粒的三种制粒工艺,评价不同制粒工艺对康眠颗粒的性质及有效成分含量的影响。以颗粒流动性、粒径分布、堆密度、吸湿性、溶化性和有效成分含量为指标,评价湿法制粒、干法制粒、一步制粒三种制粒工艺的优劣。一步制粒工艺简单,制得颗粒的流动性、溶化性和有效成分含量均优于湿法制粒和干法制粒,仅吸湿性稍差。综合各指标评价,选择一步制粒作为康眠颗粒的成型工艺方法。Objective to compare three dilfferent granulation technologies of Kangmian Granules.METHODS The drug granules obtained by wet granulation,dry granulation and fluid-bed marumerization were evaluated in fluidity,grain size distribution,bulk density,hydroscopicity,dissolution duration and the concentration.RESULTS The progress of fluid-bed marumerization was easy to process and the particles made by fluid-bed marumerization were better than the wet granulation and dry granulation in fluidity,dissolution duration and the concentration.Conclusion fluid-bed marumerization is the best one in the three granulation technologies.

关 键 词：流化床一步制粒 干法制粒 斯皮诺素 

分 类 号：TQ225.122[化学工程—有机化工]