细菌SOS修复及SOS靶位抑制剂的研究进展  

Research progress in bacterial SOS repair and development of inhibitors targeting SOS

作　　者：胡人阁 马红霞[1,2,3] 孔令聪 Hu Ren-ge;Ma Hong-xia;Kong Ling-cong(College of Animal Science and Technology,Jilin Agricultural University,Changchun 130118;Key Laboratory for Animal Production,Product Quality and Safety of Ministry of Education China,Changchun 130118;Key Laboratory for Research and Development of New Veterinary Drugs,Changchun 130118)

机构地区：[1]吉林农业大学动物科学技术学院,长春130118 [2]动物生产及产品质量安全省部共建教育部重点实验室,长春130118 [3]吉林省新兽药研发与创制重点实验室,长春130118

出　　处：《中国抗生素杂志》2021年第6期529-537,共9页Chinese Journal of Antibiotics

基　　金：国家自然科学基金青年基金(No.31702293);吉林省科技厅主题引导项目(No.20180101003JC);吉林省自然科学基金(No.20190201294JC)。

摘　　要：细菌SOS DNA损伤修复系统与细菌生长发育等多种调控息息相关,对细菌的毒力、抗药性及耐药适应性的形成产生重要影响。抗生素产生的大部分遗传变异都可归因于SOS修复反应的诱导,深入研究细菌SOS修复应答机制,研发相应的靶位抑制剂已成为了当前的研究热点。为此,本文对细菌SOS修复机制、SOS修复与细菌毒力、耐药形成的关系,以及SOS靶位抑制剂研发情况等方面做以综述,以期为细菌耐药机制的深入研究与耐药抑制剂的研发提供理论基础。Bacterial SOS DNA damage repair system affects the growth and development of bacteria, and involves many other regulations that influence virulence, drug resistance, and drug resistance adaptability of bacteria.Most of the genetic variations produced by antibiotics can be attributed to the induction of SOS repair response. Indepth study of the bacterial SOS repair response mechanism and development of the corresponding target inhibitors have become a hot direction of research. Therefore, this paper summarized the SOS repair mechanism of bacteria, the relationship between SOS repair and bacterial virulence and drug resistance development, as well as the development of inhibitors targeting SOS, so as to provide a knowledge base for the in-depth research on the mechanism of bacterial resistance and the development of inhibitors against drug resistance.

关 键 词：细菌SOS修复 毒力 耐药机制 基于SOS系统的耐药抑制剂 

分 类 号：R9[医药卫生—药学]