椎间盘退变的基因治疗研究进展  

Advances in Gene Therapy for Intervertebral Disc Degeneration

作　　者：李勇[1] 沈超 李海峰[1] 阮狄克 LI Yong;SHEN Chao;LI Haifeng;RUAN Dike(Department of Orthopedics,Chinese PLA General Hospital,Beijing 100048,China)

机构地区：[1]北京中国人民解放军总医院骨科学部,100048

出　　处：《转化医学杂志》2021年第3期197-201,共5页Translational Medicine Journal

基　　金：原海军总医院创新培育基金项目(CXPY-201818)。

摘　　要：椎间盘是一个低氧并且营养供应较为困难的组织,其独特的解剖和生理特性是进行基因治疗最主要的挑战之一。现阶段一些基因治疗在退变椎间盘中的应用已初见成效,而且不断有新技术的出现也让椎间盘退变的基因治疗再一次步入了全新的起点,本文依据近期发表的文献,将椎间盘退变的基因治疗进展综述,为将来的临床应用提供理论基础。Intervertebral disc is a tissue with low oxygen and difficult nutrition supply.Its unique anatomical and physiological characteristics are the main challenge for gene therapy of degenerative intervertebral disc.At present,the application of some gene therapy in the treatment of degenerative disc disease has achieved initial results,and the rise of new technology has also made the gene therapy of degenerative disc disease step into a new starting point again.Based on the recently published literature,the author reviewed the progress of gene therapy for intervertebral disc degeneration to provide theoretical basis for future clinical application.

关 键 词：椎间盘退变 基因治疗 病毒 基因编辑 

分 类 号：R681.5[医药卫生—骨科学]