针刺联合西药对肝肾阴虚型帕金森病患者NT-3、IGF-1、DA及炎性因子水平的影响  

Effects of Acupuncture Combined with Western Medication on the Levels of NT-3,IGF-1,DA and Inflammatory Cytokines in Patients with Parkinson’s Disease of Liver-kidney Yin Deficiency Pattern

作　　者：吴林 张光彩[1] 周晓晖[1] 冯琦钒 WU Lin;ZHANG Guang-cai;ZHOU Xiao-hui;FENG Qi-fan(Chinese Medicine Hospital of Hainan Province,Haikou 570300,China)

机构地区：[1]海南省中医院,海口570300

出　　处：《上海针灸杂志》2021年第7期814-819,共6页Shanghai Journal of Acupuncture and Moxibustion

基　　金：国家自然科学基金项目(8166150465);海南省卫生计生行业科研项目(19A200175)。

摘　　要：目的观察针刺联合西药对肝肾阴虚型帕金森病患者炎性因子、脑神经递质的影响。方法将96例肝肾阴虚型帕金森病患者,随机分为观察组和对照组,每组48例。对照组采用单纯用多巴丝肼片口服治疗,观察组在对照组治疗基础上采用针刺治疗。观察两组治疗前后血清白介素(IL)-2、白介素(IL)-6、过氧化氢酶(CAT)、神经营养因子(NT)-3、胰岛素样生长因子(IGF)-1、同型半胱氨酸(Hcy)、多巴胺(DA)水平变化及帕金森病统一评分量表(UPDRS)、蒙特利尔认知评估表(MoCA)评分变化,并比较两组临床疗效及不良反应发生情况。结果治疗后,观察组血清IL-2、IL-6、Hcy水平低于对照组,CAT、NT-3、IGF-1、DA水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗后UPDRS评分低于对照组,MoCA评分高于对照组,差异有统计学意义(P<0.05)。观察组总有效率为93.8%,高于对照组的75.0%(P<0.05)。观察组不良反应总发生率为14.6%,对照组为18.8%,差异无统计学意义(P>0.05)。结论针刺联合西药治疗肝肾阴虚型帕金森病可减轻炎症反应,稳定神经因子水平,调节脑神经递质分泌。Objective To observe the effects of acupuncture plus Western medication on the inflammatory cytokines and brain neurotransmitters in patients with Parkinson’s disease(PD)of liver-kidney yin deficiency pattern.Method Ninety-six patients with PD of liver-kidney yin deficiency pattern were randomized into an observation group and a control group,with 48 cases in each group.The control group was treated with oral administration of Levodopa and benserazide hydrochloride tablets,while the observation group was given additional acupuncture treatment.Before and after treatment,the levels of serum interleukin(IL)-2,IL-6,catalase(CAT),neurotraphic factor(NT)-3,insulin-like growth factor(IGF)-1,homocysteine(Hcy)and dopamine(DA)were observed in the two groups,as well as the scores of the unified Parkinson’s disease rating scale(UPDRS)and Montreal cognitive assessment(MoCA).Clinical efficacy and adverse reactions were compared between the two groups.Result After treatment,the serum levels of IL-2,IL-6 and Hcy were lower in the observation group than in the control group,and the levels of CAT,NT-3,IGF-1 and DA were higher in the observation group than in the control group,all with statistical significance(P<0.05).The UPDRS score was lower in the observation group than in the control group after intervention,and the MoCA score was higher in the observation group than in the control group,and the differences were statistically significant(P<0.05).The total effective rate was 93.8%in the observation group,higher than 75.0%in the control group(P<0.05).The adverse reaction rate was 14.6%in the observation group,versus 18.8%in the control group,and the difference was statistically insignificant(P>0.05).Conclusion Acupuncture plus Western medication can reduce the inflammatory reactions,stabilize the neurological factor levels and regulate the secretion of brain neurotransmitters in treating PD of liver-kidney yin deficiency pattern.

关 键 词：针刺疗法 针药并用 帕金森病 肝肾阴虚 蒙特利尔认知评估表 

分 类 号：R246.6[医药卫生—针灸推拿学]