新生儿ABO溶血的相关因素分析  

Analysis of related factors of neonatal ABO hemolysis

作　　者：吴李萍[1] 罗敏[1] 卢旭 卿克勤[1] 李红霞 WU Liping;LUO Min;LU Xu;QING Keqin;LI Hongxia(Department of Clinical Laboratory,Chengdu First People′s Hospital,Chengdu,Sichuan 610041,China)

机构地区：[1]四川省成都市第一人民医院检验科,四川成都610041

出　　处：《检验医学与临床》2021年第14期1989-1992,共4页Laboratory Medicine and Clinic

基　　金：四川省卫生健康委员会课题(20PJ188)。

摘　　要：目的分析新生儿溶血症(HDN)相关检测指标分布情况及其相关影响因素。方法回顾性分析2016—2019年孕妇抗体效价和HDN检测结果,并对孕妇年龄、孕次、胎次及患儿性别、日龄、胎龄等临床资料进行分析。结果不同血型组合夫妻抗体效价比较,差异有统计学意义(P<0.05)。HDN阳性检出率女性患儿高于男性患儿,A型患儿高于B型患儿,二胎患儿高于一胎患儿,差异均有统计学意义(P<0.05)。HDN阳性检出率在新生儿出生后24 h内最高,且随日龄增加呈逐渐下降趋势,随孕妇IgG抗体效价升高而逐渐升高。结论孕妇IgG抗体效价和胎次为HDN发生的影响因素,定期监测高风险孕妇抗体效价和尽早进行HDN试验可提高HDN的诊治效率。Objective To analyze the distribution of relevant detection indexes of neonatal hemolysis disease(HDN)and related influencing factors.Methods A retrospective analysis of the antibody titer and HDN test results of pregnant women from 2016 to 2019 was carried out,and the clinical data of the pregnant women′s age,gestation times,parity,and children′s gender,age,and gestational age were analyzed.Results There was a statistically significant difference in antibody titers between couples of different blood types(P<0.05).The positive detection rate of HDN in female children was higher than that in male children,children with type A were higher than children with type B,and children with second births were higher than those with first births,and the differences were statistically significant(P<0.05).The positive detection rate of HDN was the highest within 24 h after the birth of a newborn,and it gradually decreased with the increased of age,and gradually increased with the increased of the IgG antibody titer of pregnant women.Conclusion IgG antibody titer and parity in pregnant women are the influencing factors of HDN.Regular monitoring of antibody titer in high-risk pregnant women and early HDN test can improve the efficiency of HDN diagnosis and treatment.

关 键 词：二孩政策 抗体效价 新生儿溶血症 胎次 

分 类 号：R446.11[医药卫生—诊断学]