生物电刺激联合前列安栓治疗对慢性前列腺炎患者IL-1β、IL-6及TNF-α水平的影响  

Effect of bioelectric stimulation combined with Qianlieanshuan on the levels of IL-1β,IL-6 and TNF-αin patients with chronic prostatitis

作　　者：杜宏宏 刘凯 DU Honghong;LIU Kai(Department of Urology,the Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang,Shaanxi 712000,China)

机构地区：[1]陕西中医药大学附属医院泌尿外科,陕西咸阳712000

出　　处：《检验医学与临床》2021年第14期2034-2037,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨采取生物电刺激联合前列安栓治疗慢性前列腺炎的效果及对血清炎症因子水平的影响。方法选取80例慢性前列腺炎患者并且随机分成观察组与对照组,每组40例,对照组采取前列安栓+盐酸坦索罗辛缓释胶囊的治疗方式,观察组在对照组的基础上采用生物电刺激,比较2组治疗效果、炎症因子水平及尿动力学变化。结果观察组治疗总有效率为95.00%,高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后2组血清白细胞介素(IL)-1β、IL-6及肿瘤坏死因子-α(TNF-α)水平较治疗前降低,且观察组低于对照组(P<0.05);治疗后2组最大尿流率、最大膀胱容量与膀胱稳定性较治疗前提高,最大逼尿肌压力较治疗前降低,观察组指标变化幅度较对照组明显(P<0.05);治疗后2组慢性前列腺炎症状指数评分均较治疗前降低,前列腺炎相关的性功能指数评分较治疗前提高,且观察组评分变化幅度比对照组明显(P<0.05)。结论使用生物电刺激联合前列安栓治疗慢性前列腺炎可取得满意的疗效,降低炎症因子水平及改善尿动力水平,值得临床推广。Objective To investigate the effect of bioelectric stimulation combined with Qianlieanshuan on chronic prostatitis and its influence on serum inflammatory factor levels.Methods A total of 80 chronic prostatitis patients were selected and randomly divided into observation group and control group,40 cases in each group.The control group was treated with Qianlieanshuan+tamsulosin hydrochloride sustained release capsule,and the observation group was treated with bioelectricity on the basis of the control group.The therapeutic effect,inflammatory factor levels and urodynamic changes of the two groups were compared.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 77.50%in the control group.The difference was statistically significant(P<0.05).After treatment,the serum interleukin(IL)-1β,IL-6 and tumor necrosis factor-α(TNF-α)of the two groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the maximum urinary flow rate,maximum bladder capacity and bladder stability of the two groups increased compared with those before treatment,and the maximum detrusor pressure decreased compared with before treatment.The index change range of the observation group was more obvious than that of the control group(P<0.05).After treatment,the chronic prostatitis symptom score index of the two groups was lower than before treatment,and the prostatitis-related sexual function index score was higher than before treatment,and the score of the observation group changed significantly than that of the control group(P<0.05).Conclusion The use of bioelectric stimulation combined with Qianlieanshuan suppository in the treatment of chronic prostatitis can achieve satisfactory results,reduce the level of inflammatory factors and improve the level of urodynamics,which is worthy of clinical promotion.

关 键 词：生物电刺激 前列安栓 慢性前列腺炎 炎症因子 尿动力学 

分 类 号：R697.33[医药卫生—泌尿科学]