血清半乳糖凝集素3、脂联素、胱抑素C水平预测急性心梗患者出现心力衰竭的临床价值  

Clinical value of serum galectin-3,adiponectin and cystatin C levels in predicting heart failure in patients with acute myocardial infarction

作　　者：钟远娟 吉训宁 王文菊[1] 阳慧 ZHONG Yuanjuan;JI Xunning;WANG Wenju;YANG Hui(Department of Cardiology,People's Hospital of Dongfang,Dongfang Hainan 572600,China)

机构地区：[1]东方市人民医院内一科,海南东方572600 [2]中南大学湘雅医学院海口医院心血管内科,海南海口570208

出　　处：《中国急救复苏与灾害医学杂志》2021年第7期732-735,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：海南省卫生计生行业科研项目(编号:18A200070)。

摘　　要：目的探讨血清半乳糖凝集素3、脂联素(adiponectin,APN)、胱抑素C(cystatin C,Cys C)水平预测急性心梗患者出现心力衰竭的临床价值。方法回顾性分析东方市人民医院2017年6月-2020年6月收治的急性心梗患者96例,根据患者治疗后是否发生心力衰竭分为未发生组59例,发生组37例,另选取健康体检者45例为对照组。比较三组心功能指标、血清半乳糖凝集素3、APN、Cys C水平,采用Spearman相关性分析心功能指标与血清半乳糖凝集素3、APN、Cys C水平的关系,采用ROC曲线分析血清半乳糖凝集素3、APN、Cys C水平预测急性心梗患者心力衰竭的价值。结果发生组左心室收缩末期内径(end-systolic diameter of left ventricle,LVESD)、左心室舒张未期内径(end-diastolic diameter of left ventricle,LVEDD)明显高于未发生组和对照组(P<0.05);发生组左心室射血分数(left ventricular ejection fraction,LVEF)明显低于未发生组和对照组(P<0.05);发生组血清半乳糖凝集素3、APN、Cys C水平明显高于未发生组和对照组(P<0.05);血清半乳糖凝集素3与LVESD、LVEDD呈正相关(r=0.799,r=0.650,均P<0.05),与LVEF呈负相关(r=-0.627,P<0.05);血清APN与LVESD、LVEDD呈正相关(r=0.893,r=0.554,均P<0.05),与LVEF呈负相关(r=-0.696,P<0.05);血清Cys C与LVESD、LVEDD呈正相关(r=0.767,r=0.722,均P<0.05),与LVEF呈负相关(r=-0.712,P<0.05);当半乳糖凝集素3、APN、Cys C分别取最佳阈值10.26 ng/L、21.02 g/L、1.51 mg/L时,对急性心梗患者出现心力衰竭的预测AUC分别为0.686、0.719、0.784。结论血清半乳糖凝集素3、APN、Cys C水平对急性心梗患者出现心力衰竭具有较好预测价值,可为临床提供参考。Objective To investigate the value of galectin-3,cystatin C(Cys C)and adiponectin(APN)in the prediction of heart failure in patients with acute myocardial infarction(AMI).Methods 96 AMI patients underwent treatment in our hospital from June 2017 to June 2020 were retrospectively analyzed.Patientswere divided into two groupsaccording to the absence or presence of heart failure after treatment,non-heart failure group(n=59)and heart failure group(n=37),mean‐while,another 45 healthy individuals were set as control group.Cardiac function indexes,serum galectin-3,APN and Cys C levels were compared among three groups.Spearman correlation analysis was used to analyze the relationship amongcardiac function indexes,serum galectin-3,APN and CysClevels.ROC curve was used to analyze the value of serum galectin 3,APN and Cys C levels in predicting heart failure in AMI patients.Results end-systolic diameter of left ventricle(LVESD)and end-diastolic diameter of left ventricle(LVEDD)of heart failure group were significantly higherthan those of non-heartfailure group and controlgroup(P<0.05),and left ventricular ejection fraction(LVEF)of heart failure group was significantly lower than those of non-heart failure group and control group(P<0.05).Serum levels of galectin-3,APN and Cys C of heart failure group were all significantly higher than those of the non-heart failure group and control group(all P<0.05).The serum galectin-3 level was positively correlated with the LVESD and LVEDD(r=0.799,r=0.650,P<0.05),and was negatively correlated with LVEF(r=-0.627,P<0.05).Serum APN level was positively correlated with LVESD and LVEDD(r=0.893,r=0.554,P<0.05),and negatively correlated with LVEF(r=-0.696,P<0.05).Serum Cys C was posi‐tively correlated with LVESD and LVEDD(r=0.767,r=0.722,P<0.05),and negatively correlated with LVEF(r=-0.712,P<0.05).When the best threshold values of galectin-3,APN,and Cys C were 10.26 ng/L,21.02 g/L,and 1.51 mg/L,their predictive AUC values for heart failure were 0.686,0.719,and 0.784 respectively.Conclusion

关 键 词：半乳糖凝集素3 脂联素 胱抑素C 急性心梗 心力衰竭 

分 类 号：R196.7[医药卫生—卫生事业管理]