罗哌卡因纳米粒的制备及镇痛研究  

Prepartion and anesthetic effect of ropivacaine nanoparticles

作　　者：刘江 王艺娇[1] 赵健辉 王雪梅 刘占军 LIU Jiang;WANG Yi-jiao;ZHAO Jian-hui;WANG Xue-mei;LIU Zhan-jun(College of Pharmaceutical Sciences,North China University of Science and Technology,Tangshan Hebei 063210;Department of Anesthesiology,Tangshan Gongren Hospital,Tangshan Hebei 063000)

机构地区：[1]华北理工大学药学院,河北唐山063210 [2]唐山工人医院麻醉科,河北唐山063000

出　　处：《中南药学》2021年第6期1103-1107,共5页Central South Pharmacy

基　　金：河北省自然科学基金(No.H2018209347)。

摘　　要：目的制备罗哌卡因纳米粒,并考察其镇痛作用。方法采用RAFT法将聚甲基丙烯酸甲酯在海藻酸钠上进行接枝,然后在水中与罗哌卡因自组装成纳米粒;研究其红外光谱、热稳定性、形态及粒径分布等;测定其载药量、包封率、药物释放及在小鼠体内的镇痛作用。结果制备的罗哌卡因纳米粒热稳定性好;粒度基本均匀,粒径为(287.3±5.6)nm;最大载药量和包封率分别为(4.31±0.22)%和(90.4±3.1)%;载药纳米粒在小鼠体内表现出持久的麻醉作用。结论制备的罗哌卡因纳米粒可明显延长镇痛时间。Objective To prepare ropivacaine nanoparticles and to study its anesthetic effect.Methods Poly(methyl methacrylate)was grafted onto sodium alginate with the RAFT method,and then selfassembled into nanoparticles with ropivacaine in water.The infrared spectrum,thermal stability,morphology,particle size and distribution were studied.The drug loading and encapsulation rate,as well as the analgesic effect in mice were measured.Results The ropivacaine nanoparticles showed good thermal stability,with particle size of(287.3±5.6)nm.The maximum drug loading and encapsulation efficiency were(4.31±0.22)%and(90.4±3.1)%.The ropivacaine nanoparticles showed a long-lasting anesthetic effect in mice.Conclusion The prepared ropivacaine nanoparticles have long-term local anesthesic effect.

关 键 词：罗哌卡因纳米粒 海藻酸钠 聚甲基丙烯酸甲酯 镇痛作用 

分 类 号：R943[医药卫生—药剂学]