肿瘤微环境响应型药物递送系统研究进展  

Research progress in tumor microenvironment-responsive drug delivery system

作　　者：杨锦昱 谢锦珊 白菁钰 周宏磊 程迪 朱维平 YANG Jin-yu;XIE Jin-shan;BAI Jing-yu;ZHOU Hong-lei;CHENG Di;ZHU Wei-ping(Department of Pharmaceutical Engineering,School of Pharmacy,East China University of Science and Technology,Shanghai 200237;Institute of Pesticide and Pharmaceuticals,School of Pharmacy,Shanghai Key Laboratory of Chemical Biology,East China University of Science and Technology,Shanghai 200237)

机构地区：[1]华东理工大学药学院制药工程系,上海200237 [2]华东理工大学药学院药物化工研究所,上海市化学生物学重点实验室,上海200237

出　　处：《中南药学》2021年第6期1219-1227,共9页Central South Pharmacy

基　　金：华东理工大学大学生创新创业训练计划项目(No.X19101)。

摘　　要：肿瘤微环境是一个极其复杂的内部微环境系统。一方面,复杂的肿瘤微环境对药物递送造成了障碍,极大地降低了药物递送系统的递送效率,为肿瘤的治疗带来了巨大阻碍;另一方面,研究者可针对其特定微环境设计特异微环境响应型药物递送系统,实现药物在肿瘤组织的靶向递送。本文综述了基于肿瘤微环境响应的可降解药物递送系统的设计,主要从肿瘤微环境的低pH、乏氧、高谷胱甘肽、高活性氧四个方面展开,为研究肿瘤的多模态治疗提供参考。The tumor microenvironment is an extremely complex internal microenvironment system.On the one hand,the complex tumor microenvironment has caused obstacles to drug delivery,greatly reducing the efficiency of the drug delivery system in tumor treatment.On the other hand,we can design a specific microenvironment-responsive drug delivery system to achieve targeted delivery of drugs in tumor tissues.This article reviewed the design of the degradable drug delivery system based on the tumor microenvironment response from four aspects of the tumor microenvironment:low pH,hypoxia,high glutathione and high reactive oxygen,to provide methodological reference for research of multimodal treatment of cancer.

关 键 词：肿瘤微环境 多模态治疗 药物递送系统 刺激响应 可降解 

分 类 号：R94[医药卫生—药剂学]