(+)-/(-)-Angelignanine,a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head  

作　　者：Youzhe Chen Qinglan Guo Chengbo Xu Chenggen Zhu Jianjun Zhang Jiangong Shi 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China

出　　处：《Chinese Chemical Letters》2021年第5期1657-1659,共3页中国化学快报（英文版）

基　　金：Financial support from the National Natural Sciences Foundation of China(No.81630094);CAMS Innovation Fund for Medical Science(No.2017-I2M-3-010);The Drug Innovation Major Project(No.2018ZX09711001-001)is acknowledged.

摘　　要：A pair of neolig nan enan tiomers with an unprecedented carb on skelet on,(+)-/(-)-angeligna nine[(+)-/(-)-1].was isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Their structures were determined by spectroscopic data analysis and the absolute configurations were assigned by the circular dichroism(CD)exciton chirality method as well as electronic CD quantum calculations.The enantiomers represent the first 2,7/-cyclo-8,9z-neolignans,of which biosynthetic pathways originating from precursors ferulic acid and coniferyl alcohol is proposed.In an in vivo test,both the enantiomers showed significant hypnotic effects at a dose of 10 mg/kg(i.g.).

关 键 词：UMBELLIFERAE Angelica sinensis NEOLIGNAN 2 7/-Cyclo-8 9/-neolignan (+)-/(-)-Angelignanine 

分 类 号：TQ460.1[化学工程—制药化工]