Convenient synthesis of hexasubstituted benzene derivatives via DABCO promoted domino reaction of arylidene malononitrile and dialkyl but-2-ynedioate  

作　　者：Hui Zheng Ying Han Jing Sun Chao-Guo Yan 

机构地区：[1]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Chemical Letters》2021年第5期1683-1686,共4页中国化学快报（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(No.21572196);the Priority Academic Program Development of Jiangsu Higher Education Institutions.

摘　　要：A convenient synthetic protocol for the hexasubstituted benzene derivatives was successfully developed by DABCO promoted domino reaction of arylidene malononitrile with two molecules of dialkyl but-2-ynedioates.The domino reaction resulted in tetraalkyl 6-cyano-[1,1'-biphenyl]-2,3,4,5-tetracarboxylates in good to high yields.This formal[2+2+2]cycloaddition was believed to proceed with sequential nucleophilic addition.Michael addition,annulation and aromatization processes.

关 键 词：Hexasubstituted benzene Electron-deficient alkyne MALONONITRILE ANNULATION [2+2+2]cycloaddition 

分 类 号：O621.251[理学—有机化学]