Rh(Ⅲ)-catalyzed annulation of azobenzenes and α-Cl ketones toward 3-acyl-2H-indazoles  

作　　者：Huan Li Yuxuan Han Zi Yang Zhenyu Yao Lianhui Wang Xiuling Cui 

机构地区：[1]Engineering Research Centre of Molecular Medicine of Ministry of Education,Key Laboratory of Fujian Molecular Medi-cine,Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities,Key Laboratory of Xiamen Marine and Gene Drugs,School of Biomedical Sciences,Huaqiao University,Xiamen 361021,China

出　　处：《Chinese Chemical Letters》2021年第5期1709-1712,共4页中国化学快报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.21572072);111 Project(No.BC 2018061);Xiamen Southern Oceanographic Center(No.15PYY052SF01).

摘　　要：Rhodium(Ⅲ)-catalyzed[4+1]cyclization of azobenzenes with α-Cl ketones has been developed.3-Acyl-2H-indazoles could be easily afforded in up to 97%yields for more than 30 examples.The obtained products are potentially valuable in organic synthesis and drug discovery.This protocol featured with high efficiency,extensive functional group tolerance and mild reaction conditions.The one-step efficient construction of an anti-inflammatory agent confirms the practicability of this procedure.

关 键 词：Rh(Ⅲ)-catalyzed C-H activation/cyclization α-Cl Ketones 3-Acyl-2H-indazoles 

分 类 号：O626[理学—有机化学]