来曲唑联合地屈孕酮治疗多囊卵巢综合征不孕患者的临床效果及对血清孕酮水平的影响分析  

Analysis of clinical effect of letrozole combined with dydrogesterone in the treatment of infertility patients with polycystic ovary syndrome and its influence on serum progesterone level

作　　者：阮忠敏 刘秀青 RUAN Zhong-min;LIU Xiu-qing(Obstetrics and Gynecology Department,Yanggu County People’s Hospital,Liaocheng 252300,China)

机构地区：[1]阳谷县人民医院妇产科,252300

出　　处：《中国现代药物应用》2021年第13期18-21,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探究多囊卵巢综合征不孕患者采用来曲唑+地屈孕酮共同治疗的临床效果。方法96例多囊卵巢综合征不孕患者,依据奇偶顺序分为对照组及观察组,各48例。对照组接受来曲唑单独治疗,观察组接受来曲唑+地屈孕酮联合治疗。对比两组患者的激素[促黄体生成素(LH)、血清孕酮(SP)、雌二醇(E_(2))]水平、子宫内膜厚度及卵泡直径、排卵率及妊娠率、临床疗效。结果治疗后,两组LH较治疗前下降,SP、E_(2)较治疗前升高,且观察组LH(8.17±1.01)IU/L低于对照组的(12.33±1.55)IU/L,SP(18.55±3.68)ng/ml、E_(2)(95.45±9.75)pg/ml高于对照组的(15.64±3.01)ng/ml、(78.78±8.84)pg/ml,差异具有统计学意义(P<0.05)。治疗后,观察组的子宫内膜厚度(11.27±0.89)mm、卵泡直径(11.21±0.83)mm大于对照组的(9.66±0.73)、(9.46±0.55)mm,差异具有统计学意义(P<0.05)。观察组的排卵率79.17%及妊娠率62.50%高于对照组的52.08%、27.08%,差异具有统计学意义(P<0.05)。观察组治疗总有效率93.75%高于对照组的70.83%,差异具有统计学意义(P<0.05)。结论来曲唑+地屈孕酮治疗方案,相比来曲唑单独治疗,在改善多囊卵巢综合征不孕患者激素水平、卵巢状态、提高排卵率、妊娠率及临床效果方面具备更加理想的治疗效果,拥有较高的医学研究价值,值得临床推广应用。Objective To investigate the clinical effect of letrozole combined with dydrogesterone in the treatment of infertility patients with polycystic ovary syndrome.Methods A total of 96 patients with polycystic ovary syndrome were divided into control group and observation group according to odd-even number method,with 48 cases in each group.The control group was treated with letrozole,and the observation group was treated with letrozole and dydrogesterone.The hormone[luteinizing hormone(LH),serum progesterone(SP),estradiol(E_(2))]levels,endometrial thickness and follicle diameter,ovulation rate,pregnancy rate,clinical efficacy were compared between the two groups.Results After treatment,the LH of the two groups were lower than those before treatment,and SP and E_(2) were higher than those before treatment;the LH(8.17±1.01)IU/L of the observation group was lower than(12.33±1.55)IU/L of the control group,and SP(18.55±3.68)ng/ml and E_(2)(95.45±9.75)pg/ml of the observation group were higher than(15.64±3.01)ng/ml and(78.78±8.84)pg/ml of the control group.All the difference was statistically significant(P<0.05).After treatment,the endometrial thickness(11.27±0.89)mm and follicle diameter(11.21±0.83)mm of the observation group were larger than(9.66±0.73)and(9.46±0.55)mm of the control group,and the difference was statistically significant(P<0.05).The ovulation rate 79.17%and pregnancy rate 62.50%of the observation group were higher than 52.08%and 27.08%of the control group,and the difference was statistically significant(P<0.05).The total effective rate 93.75%of the observation group was higher than 70.83%of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with letrozole,combination of letrozole and dydrogesterone has more ideal therapeutic effect in improving hormone level,ovarian status,ovulation rate,pregnancy rate and clinical effect of infertility patients with polycystic ovary syndrome.It has higher medical research value and is worthy of clinical promotion and

关 键 词：多囊卵巢综合征 不孕 地屈孕酮 来曲唑 血清孕酮 临床疗效 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]