Bioinformatics-based Identification of Key Pathways and Hub Genes of Traumatic Brain Injury in a Rat Model  

作　　者：Xin-yi CAO Xiao QIAN Guo-dong LIU Yu-hai WANG 

机构地区：[1]Wuxi Clinical College of Anhui Medical University(904th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army),Wuxi 214000,China

出　　处：《Current Medical Science》2021年第3期610-617,共8页当代医学科学（英文）

基　　金：the Military Logistics Scientific Research Project(No.CLB20J027).

摘　　要：Traumatic brain injury(TBI)is a common injury caused by external forces that lead to damaged brain function or pathological changes in the brain tissue.To explore the molecular mechanism and the hub genes of TBI,we downloaded gene expression profiles of the TBI model of rat and the sham control for the subsequent gene set enrichment analysis,pathway analysis and protein-protein interactions analysis.The results of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis indicated that multiple biological pathways,including immune response,inflammatory response and cellular response to interleukin-1,as well as signaling pathways,such as tumor necrosis factor signaling pathway,chcmokine signaling pathway,cytokine-cytokine receptor interaction,Toll-like receptor signaling pathway and nuclear factor kappa B signaling pathway were implicated in the TBI.In conclusion,this study provides insights into the molecular mechanism of TBI by screening the differentially expressed genes and hub genes that can be used as biomarkers and therapeutic targets.

关 键 词：traumatic brain injury bioinformatics analysis differentially expressed gene hub gene signal pathway 

分 类 号：R65[医药卫生—外科学]