2010—2020年HIV感染者疾病进程及影响因素分析  

Analysis of disease progression and influencing factors of HIV-infected persons in 2010-2020

作　　者：张玲 林昌锋[1] 孙霞 温煦 符式景 ZHANG Ling;LIN Changfeng;SUN Xia;WEN Xu;FU Shijing(Department of Infection,Hainan Provincial Third People′s Hospital,Haikou 572000,China)

机构地区：[1]海南省第三人民医院感染科,海南572000

出　　处：《公共卫生与预防医学》2021年第4期88-91,共4页Journal of Public Health and Preventive Medicine

摘　　要：目的探讨三亚地区2010—2020年内艾滋病病毒(HIV)感染者的疾病进程并分析其影响因素。方法通过国家艾滋病综合防治信息系统收集2010年1月至2020年1月三亚地区报告的HIV感染者资料。通过寿命计算法计算艾滋病发病率,从性别、年龄、BMI、民族、婚姻状况、文化程度、高效抗逆转录病毒治疗(HAART)情况、贫血情况、传播途径、CD_(4)^(+)细胞计数、合并其他病毒感染等方面分析影响HIV感染者疾病进程的单因素,采用Cox回归模型分析影响HIV感染者疾病进程的独立危险因素。结果2010年1月至2020年1月三亚地区共报告HIV感染者761例,其中103名进展为艾滋病(13.53%),艾滋病发病密度为6.01/100人年,平均潜伏期为7.63年,死亡病例31名,全死因死亡率1.81/100人年;性别、年龄、HAART治疗情况、贫血、CD_(4)^(+)细胞计数、合并其他病毒感染是影响HIV感染者疾病进展的单因素(χ^(2)=16.803、13.362、15.954、20.119、16.039、15.711,P<0.05);年龄、HAART治疗情况、贫血、CD_(4)^(+)细胞计数、合并其他病毒感染是影响HIV感染者疾病进展的独立危险因素(P=0.014、0.007、0.017、0.009、0.001、0.001)。结论潜伏期是HIV感染者病情进展的重要阶段,年龄、HAART治疗情况、贫血、CD_(4)^(+)细胞计数、合并其他病毒感染等均是影响HIV感染者疾病进展的独立危险因素。Objective To investigate the disease progression and influencing factors of human immunodeficiency virus(HIV)-infected persons in Sanya area from 2010-2020.Methods Data of HIV infected cases reported in XX region from January 2014 to January 2020 were collected through the National AIDS Comprehensive Prevention and Control Information System.The incidence of AIDS was calculated by the life expectancy method,and the single factors influencing the progression of HIV infection were analyzed from the aspects of sex,age,BMI,nationality,marital status,educational level,highly active anti-retroviral therapy(HAART),anemia,route of transmission,CD_(4)^(+) cell count,and co-infection of other viruses.Results A total of 761 HIV-infected cases were reported in Sanya areaFrom January 2010 to January 2020,of which 103 had progressed to AIDS(13.53%),the incidence of AIDS was 6.01/100 person-years,the average incubation period was 7.63 years;There were 31 death cases,and the all-cause mortality rate was 1.81/100 person years;Gender,age,HAART treatment status,anemia,CD_(4)^(+) cell count,and other viral infections were single factors that affect the disease progression of HIV-infected persons(χ^(2)=16.803,13.362,15.954,20.119,16.039,15.711,P<0.05),meanwhile,age,HAART treatment status,anemia,CD_(4)^(+) cell count,and other viral infections were independent risk factors that affect the disease progression of HIV-infected persons(P=0.014,0.007,0.017,0.009,0.001,0.001).Conclusion The incubation period is an important stage of the disease progression of HIV-infected patients,moreover,age,HAART treatment status,anemia,CD_(4)^(+) cell count,and other viral infections are all independent risk factors that affect the disease progression of HIV-infected patients.

关 键 词：艾滋病毒 潜伏期 进程 

分 类 号：R183[医药卫生—流行病学] R512.91[医药卫生—公共卫生与预防医学]