大气细颗粒物组分暴露对缺血性心脏病的影响研究进展  

Research progress on adverse effects of fine particulate matter constituent exposure on ischemic heart disease

作　　者：李颖欣 许瑞君 张海[2] 张岚[3] 孙宏[4] 周芸 刘跃伟 LI Yingxin;XYU Ruijun;ZHANG Hai;ZHANG Lan;SUN Hong;ZHOU Yun;LIU Yuewei(School of Public Health,Sun Yat-sen University,Guangzhou 510080,China;Institute of Health Surveillance,Analysis and Protection,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China;Institute of Chronic Noncommunicable Disease Control and Prevention,Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China;Department of Environment and Health,Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China;School of Public Health,Guangzhou Medical University,Guangzhou 511436,China)

机构地区：[1]中山大学公共卫生学院,广州510080 [2]湖北省疾病预防控制中心卫生监测检验防护所 [3]湖北省疾病预防控制中心慢性病防治研究所 [4]江苏省疾病预防控制中心环境与健康所 [5]广州医科大学公共卫生学院

出　　处：《公共卫生与预防医学》2021年第4期120-125,共6页Journal of Public Health and Preventive Medicine

基　　金：湖北省卫生健康委员会重点支撑项目(WJ2019Z016);国家自然科学基金重点项目(91743205)。

摘　　要：大气细颗粒物(fine particulate matter,PM_(2.5))由碳质气溶胶、水溶性离子和无机元素等多种化学物质组成,组分十分复杂,是我国多数城市的首要污染物。研究表明,大气PM_(2.5)暴露可损伤心血管系统,增加缺血性心脏病(ischemic heart disease,IHD)的发生和死亡风险,但PM_(2.5)具体组分暴露对IHD的影响尚不明确,且其致病机制尚未阐明。就PM_(2.5)组分短期及长期暴露对IHD的影响研究进展进行综述,以期为后续相关研究提供参考依据。Ambient fine particulate matter(PM_(2.5))is a mixture consisting of a wide range of chemical constituents including carbonaceous aerosols,water soluble ions and inorganic elements,and has become the major air pollutant in most cities in China.Evidence suggests that exposure to ambient PM_(2.5) induces damage on the cardiovascular system and can increase risk of the development and mortality of ischemic heart diseases(IHD).However,the effects of exposure to specific PM_(2.5) constituents on IHD remain unclear,and its underlying mechanisms are yet to be investigated.Here we reviewed studies investigating the association of short-and long-term exposure to specific PM_(2.5) constituents with IHD,which may provide useful clues for future relevant studies.

关 键 词：细颗粒物 细颗粒物组分 缺血性心脏病 

分 类 号：R122.2[医药卫生—环境卫生学]