剪切波弹性成像技术定量评价亚临床性甲状腺功能减退症患者颈动脉弹性  

Shear wave elastography for quantitative evaluation on carotid elasticity in patients with subclinical hypothyroidism

作　　者：冯晓蕾[1] 何鑫[1] 周琦[1] 姜珏[1] FENG Xiaolei;HE Xin;ZHOU Qi;JIANG Jue(Laboratory of Ultrasound,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,China)

机构地区：[1]西安交通大学第二附属医院超声研究室,陕西西安710004

出　　处：《中国医学影像技术》2021年第7期989-992,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(81871366)。

摘　　要：目的观察剪切波弹性成像(SWE)技术定量评价亚临床性甲状腺功能减退症(SCH)患者颈动脉弹性的价值,并与射频超声技术进行对比。方法纳入84例SCH患者(观察组)及82名健康志愿者(对照组),以射频超声技术获取双侧颈动脉内-中膜厚度(IMT)、膨胀系数(DC)、顺应系数(CC)、α系数、β系数及脉搏波传导速度(PWV),以SWE技术测量平均、最大及最小弹性模量(ME_(mean)、ME max、ME min),并比较各参数组间差异。采用线性回归评价各射频超声参数与ME_(mean)间相关性。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评价ME_(mean)诊断SCH患者动脉弹性改变的效能。结果观察组DC及CC均明显低于对照组(P均<0.05),α系数、β系数、PWV、ME_(mean)及ME max均明显高于对照组(P均<0.05)。α系数、β系数、PWV与ME_(mean)均呈正相关(r=0.453、0.521、0.717,P均<0.05)。ME_(mean)预测SCH患者动脉弹性改变的AUC为0.822,敏感度为76.2%,特异度为63.8%。结论SWE技术可用于评价SCH患者颈动脉弹性改变。Objective To observe the value of shear wave elastography(SWE)for quantitative evaluation on carotid elasticity in patients with subclinical hypothyroidism(SCH)compared with the radio frequency ultrasound technology.Methods A total of 84 cases of SCH patients(study group)and 82 healthy volunteers(control group)were enrolled.The intima-media thickness(IMT),distention coefficient(DC),compliance coefficient(CC),αcoefficient,βcoefficient and pulse wave velocity(PWV)of bilateral carotid artery were measured with the radio frequency ultrasound technology,while the mean elastic modulus of elasticity(ME_(mean)),the maximum modulus of elasticity(ME max)and minimum modulus of elasticity(ME min)were measured with SWE.The above parameters were compared between groups.Linear regression was used to evaluate the correlation of the parameters and ME_(mean).The receiver operating characteristic(ROC)curves were drawn to calculate the area under the curve(AUC)for assess the efficacy of ME_(mean)in evaluating elasticity in patients with SCH.Results DC and CC in study group were significantly lower than those in control group(all P<0.05),whileαcoefficient,βcoefficient,PWV,ME_(mean)and ME max were significantly higher than those in control group(all P<0.05).ME_(mean)was positively related toαcoefficient,βcoefficient and PWV(r=0.453,0.521,0.717,all P<0.05).The AUC of ME_(mean)for predicting arterial elasticity changes of SCH patients was 0.822,with the sensitivity of 76.2%and the specificity of 63.8%.Conclusion SWE could quantitatively evaluate the changes of carotid elasticity in SCH patients.

关 键 词：甲状腺功能减退症 颈动脉 弹性成像技术 

分 类 号：R543.4[医药卫生—心血管疾病] R445.1[医药卫生—内科学]