嘌呤受体信号通路在肺部疾病中的作用  

The role of purinoceptor signaling pathway in lung diseases

作　　者：黄麒 胡庆华[1] HUANG Qi;HU Qinghua(College of Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,江苏南京211198

出　　处：《药学研究》2021年第6期400-405,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金面上项目(No.NSFC81872867、NSFC81773745)。

摘　　要：嘌呤能G蛋白偶联受体是人体中表达较为丰富的一类G蛋白偶联受体。嘌呤能受体在心肺系统广泛分布,几乎所有肺实质和间质细胞中均存在多种受体亚型的表达,说明了嘌呤能信号系统在肺组织中发挥重要生理作用。本文重点阐述肺部疾病尤其是哮喘、急性肺损伤、囊性肺纤维化、远端肺动脉高压中嘌呤能受体的作用。Purinergic G protein-coupled receptors are a type of G protein-coupled receptors that are abundantly expressed in humans.Purinergic receptors are widely distributed in the cardiopulmonary system.Almost all lung parenchyma and interstitial cells have the expression of multiple receptor subtypes,indicating that the purinergic signaling system plays an important physiological role in lung tissue.This article will expound the role of purinoceptor in lung diseases,especially asthma,acute lung injury,cystic pulmonary fibrosis,and distal pulmonary hypertension.

关 键 词：嘌呤受体信号通路 肺部疾病 机制研究 

分 类 号：R563[医药卫生—呼吸系统]