适配体AS1411功能化纳米材料的合成和生物应用进展  

Progress in the Synthesis and Biological Applications of Aptamer AS1411-functionalized Nanomaterials

作　　者：杜悦溶 爱军[1,2] DU Yue-ronga;AI Jun(College of Chemistry and Environmental Science,Inner Mongolia Normal University,Hohhot 010022,Chin;Inner Mongolia Key Lab of Environmental Chemistry,Inner Mongolia Normal University,Hohhot 010022,China)

机构地区：[1]内蒙古师范大学化学与环境科学学院,内蒙古呼和浩特010022 [2]内蒙古师范大学内蒙古自治区环境化学重点实验室,内蒙古呼和浩特010022

出　　处：《化学试剂》2021年第7期917-924,共8页Chemical Reagents

基　　金：国家自然科学基金资助项目(21864020);内蒙古自然科学基金资助项目(2018MS02012)。

摘　　要：纳米技术的发展,给一些重大疾病的诊断和治疗提供了新方法,人们发现利用寡核苷酸可以靶向各种癌蛋白。AS1411是一种富含26个碱基的鸟嘌呤寡核苷酸,可形成稳定的二聚G-四链体结构。由于它的特异性高、亲和力强、免疫原性小,不仅可以特异性结合癌细胞上过度表达的靶核仁素受体,还可以和其他卟啉类衍生物特异性结合,有望用于肿瘤治疗及诊断,目前在Ⅱ期临床试验中评估为抗癌药。结合近几年国内外学者的相关研究,对AS1411功能化纳米材料的合成与在生物领域的应用进展进行了综述。The development of nanotechnology has provided new methods for the diagnosis and treatment of some major diseases.It has been found that oligonucleotides can be used to target various cancer proteins.AS1411 is a 26-base guanine oligonucleotide that can form a stable dimeric G-quadruplex structure.Because of its high specificity, strong affinity, and low immunogenicity, it can realize specifical bindings to the target nucleolin receptor overexpressed on cancer cells, and to other porphyrin derivatives.Therefore, it is of great promisefor tumor treatment and diagnosis, and currently being evaluated as an anticancer drug in phase Ⅱ clinical trials.Synthesis and applications of AS1411-functionalized nanomaterials were reviewed with respect to the current related researches from domestic and international scholars.

关 键 词：AS1411 纳米材料 癌症 药物 核酸适配体 

分 类 号：O65[理学—分析化学]