基于糖基化修饰非铂类抗肿瘤制剂研究进展  

Research advances of non-platinum antitumor compounds based upon glycosylation

作　　者：邵佳[1] 张强 李绍青 刘薇 刘卫星 田金磊 魏金霞 SHAO Jia;ZHANG Qiang;LI Shao-qing;LIU Wei;LIU Wei-xing;TIAN Jin-lei;WEI Jin-xia(Department of Pharmacy,Tianjin First Central Hospital,Tianjin 300192,China;College of Chemistry,Nankai University,Tianjin 300071,China;Department of Military Pharmacy,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津市第一中心医院药学部,天津300192 [2]南开大学化学学院,天津300071 [3]天津中医药大学中药学院,天津301617

出　　处：《中国医院药学杂志》2021年第13期1366-1371,共6页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81803356);天津市自然科学基金项目(编号:20JCQNJC01810);天津市卫生健康科技项目(编号:ZC20212)。

摘　　要：铂类药物是众多恶性肿瘤的重要治疗药物之一,但靶向性弱,毒副作用强;与铂类金属药物相比,部分非铂类金属化合物前期研究展现出良好的抗肿瘤活性和较低的毒性。近期研究表明,糖基化金属化合物不但提高了化合物的靶向性,还可进一步降低毒性,并且还展现出除抗肿瘤以外的其他药用价值,如杀菌、抗病毒、抗疟疾等。鉴于此,本文尝试总结近年非铂类糖基金属化合物的研究进展,并对目前糖基金属类化合物存在的问题进行了分析与展望,期望为非铂类抗肿瘤制剂的研发提供借鉴。With weak targeting and obvious side effects,platinum-based agents are one of the most important drugs for many malignant tumors.Compared with platinum compounds,non-platinum metal compounds have demonstrated potent antitumor effects with a low toxicity.Recent studies have confirmed that glycosylated metal compounds not only improved targeting,but also reduced the toxicity.And there are other medicinal values of sterilization,anti-virus and anti-malaria.This review summarized the latest researches of non-platinum glycosylated metal compounds and the existing problems were addressed.It was expected to provide references for research and development of non-platinum anti-tumor agents.

关 键 词：糖基化 非铂类金属化合物 生物活性 

分 类 号：R944[医药卫生—药剂学]