苗药芭蕉根化学成分研究(Ⅲ)  

Chemical Constituents from Rhizomes of Musa Basjoo(Ⅲ)

作　　者：黄鸿运 蒋礼 杨贵香 汪洋 马雪[1] 潘洁[3] 李勇军[1] HUANG Hongyun;JIANG Li;YANG Guixiang;WANG Yang;MA Xue;PAN Jie;LI Yongjun(Engineering Research Center for the Development and Application of Ethnic Medicine and TCM·State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University,Guiyang,Guizhou,China 550004;School of Pharmacy,Guizhou Medical University,Guiyang,Guizhou,China 550004;Guizhou Provincial Key Laboratory of Pharmaceutics,Guizhou Medical University,Guiyang,Guizhou,China 550004)

机构地区：[1]贵州医科大学民族药与中药开发应用教育部工程研究中心·省部共建药用植物功效与利用国家重点实验室,贵州贵阳550004 [2]贵州医科大学药学院,贵州贵阳550004 [3]贵州医科大学贵州省药物制剂重点实验室,贵州贵阳550004

出　　处：《中国药业》2021年第14期45-48,共4页China Pharmaceuticals

基　　金：国家自然科学基金委员会-贵州省人民政府联合基金项目[U1812403];贵州省科技计划项目[黔科合平台人才[2016]5677];中央引导地方科技发展专项资金项目[黔科中引地[2018]4006]。

摘　　要：目的研究苗药芭蕉根的化学成分。方法从芭蕉根70%乙醇提取物中,以D101型大孔树脂、正相硅胶柱,以及Sephadex LH-20、Toyopearl HW-40F、Toyopearl HW-40C凝胶柱等分离纯化,结合化合物波谱数据与文献数据比对,鉴定化合物结构。结果分离并鉴定了7个化合物,分别为cyclomusalenone(1)、rubiprasinA(2)、1-甲基-环戊烯(3)、leonuriside A(4)、2-hydroxy-9-phenylphenalen-1-one(5)、2-(3',4'-二羟基苯基)-1,3-苯并二茂恶-5-甲醛(6)、2-hydroxy-1H-phenalen-1-one(7)。结论化合物2,3,6首次从该属植物中分离得到,化合物4和7为首次从芭蕉根中分离得到,化合物3首次归属了其碳氢波谱数据,为芭蕉根的进一步研究提供了理论依据和参考。Objective To study chemical constituents from rhizomes of Musa basjoo.Methods The chemical compounds were separated and purified from 70%ethanol extract of rhizomes of Musa basjoo by using D101 macroporous resins,silica gel column,Sephadex LH-20,Toyopearl HW-40 F and Toyopearl HW-40 C gel column.The structures of the compounds were identified by comparing the spectral data with the data in the literature.Results Seven compounds were isolated and identified as cyclomusalenone(1),rubiprasin A(2),1-methyl-cyclopentene(3),leonuriside A(4),2-hydroxy-9-phenyl-phenalen-1-one(5),2-(3’,4’-dihy droxyphenyl)-1,3-benzodioxole-5-carboxaldehyde(6),2-hydroxy-1 H-phenalen-1-one(7).Conclusion Compounds 2,3 and 6 are isolated from Musa basjoo for the first time,compounds 4,7 are isolated from rhizomes of Musa basjoo for the first time,compound 3 is assigned to its hydrocarbon spectrum data for the first time,which can provide a theoretical basis and reference for further study of rhizomes of Musa basjoo.

关 键 词：芭蕉根 化学成分 分离 鉴定 1-甲基-环戊烯 

分 类 号：R932[医药卫生—生药学] R284.1[医药卫生—药学]