紫草化学成分对肺、肝、结肠癌细胞作用的研究进展  

Research Progress of Chemical Constituents from Arnebiae Radix on Lung,Liver and Colon Cancer Cells

作　　者：于静[1] 曹书立 焦国正 张松[1] YU Jing;CAO Shuli;JIAO Guozheng;ZHANG Song(Department of Pharmacy,Huangshi Central Hospital·Affiliated Hospital of Hubei Polytechnic University,Edong Healthcare Group,Huangshi,Hubei,China 435000;Department of Chinese Medicine Rehabilitation,The 948th Hospital of PLA,Wusu,Xinjiang,China 833000;Chemistry and Chemical Engineering Institute,Taishan University,Tai'an,Shandong,China 271000)

机构地区：[1]鄂东医疗集团黄石市中心医院·湖北理工学院附属医院药学部,湖北黄石435000 [2]中国人民解放军陆军第948医院中医康复科,新疆乌苏833000 [3]泰山学院化学化工学院,山东泰安271000

出　　处：《中国药业》2021年第14期128-128,I0001-I0005,共6页China Pharmaceuticals

基　　金：国家自然科学基金[81803835];泰山学院引进人才项目[Y-01-2016014]。

摘　　要：目的探讨紫草化学成分对肺、肝、结肠癌细胞的作用及机制。方法采用计算机检索近10年来中国期刊全文数据库、万方数据库,以及Web of Science,PubMed,Elsevier,Wiley,Springerlink,ACS,RSC等数据库有关紫草化学成分抑制肺、肝、结肠癌细胞的研究,并进行分析、总结、归纳。结果紫草中紫草素、萜类、多糖等多种化学成分可通过调节细胞信号通路、作用于线粒体、调控蛋白酶、阻断细胞周期和抑制细胞迁移、调节蛋白表达、抑制细胞增殖与抗耐药性来抑制癌细胞的生长。结论紫草多种化学成分在体外抑瘤试验中均显示出对肺、肝和结肠癌细胞生长的良好抑制效果,但对机体肿瘤组织的抑制效果与机制需进一步研究。Objective To investigate the effect and mechanism of chemical constituents from Arnebiae Radix on lung,liver and colon cancer cells.Methods The researches of the inhibitory effect of chemical constituents from Arnebiae Radix on lung,liver and colon cancer cells in the past 10 years were retrieved from the CNKI,Wanfang,Web of Science,PubMed,Elsevier,Wiley,Springerlink,ACS,RSC and other databases,and the search results were analyzed,reviewed,and summarized.Results Shikonin,terpenoids,polysaccharides and other chemical constituents from Arnebiae Radix could inhibit the growth of cancer cells by regulating cell signaling pathway,acting on mitochondria,regulating protease,blocking cell cycle and inhibiting cell migration,regulating protein expression,inhibiting cell proliferation and resistance.Conclusion Various chemical constituents from Arnebiae Radix have shown a good inhibitory effect on the growth of lung,liver and colon cancer cells in vitro,but its inhibitory effect and mechanism on body tumor tissue need to be further studied.

关 键 词：紫草 紫草素 肺癌 肝癌 结肠癌 细胞 作用机制 进展 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]