重组牛疱疹病毒I型疫苗的研制现状  

The status of research on bovine herpesvirus type 1-based vaccines

作　　者：李文桂[1] 陈雅棠[1] LI Wen-gui;CHEN Ya-tang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所,重庆400016

出　　处：《中国病原生物学杂志》2021年第6期724-727,共4页Journal of Pathogen Biology

基　　金：国家自然科学基金项目(No.30801052,30671835,30500423,30200239)。

摘　　要：牛疱疹病毒I型(BHV-1)是牛传染性鼻气管炎的病原体。BHV-1可诱导感染的宿主产生细胞、体液和粘膜免疫应答,是一种理想的疫苗载体,可表达病毒的多种蛋白和细胞因子。以BHV-1为载体的疫苗包括:伪狂犬病毒(rBHV-gB/gC/gD/gE/gI)、口蹄疫病毒(rBHV-VP1)、牛呼吸道合胞病毒(rBHV-Gsyn)、兔出血热病毒(rBHV-VP60)、牛病毒性腹泻病毒(rBHV-E2)、细胞因子(rBHV-IL-1/IFN-γ、rBHV-IL-2/IL-4、rBHV-GM-CSF、rBHV-HDAF和BHV-IRP1)等,本文将综述这些BHV-1介导的疫苗的研制现状。Bovine herpesvirus type 1(BHV-1),the pathogen responsible for bovine infectious rhinotracheitis,may induce the host to produce cellular,humoral,and mucosal immune responses.BHV-1 it may be an ideal vaccine vector to express numerous viral proteins and cytokines.These BHV-1-based vaccines include Pseudorabies virus(rBHV-gB/gC/gD/gE/gI),foot and mouth disease virus(rBHV-VP1),bovine respiratory syncytial virus(rBHV-Gsyn),rabbit hemorrhagic disease virus(rBHV-VP60),bovine viral diarrhea virus(rBHV-E2),and cytokines(rBHV-IL-1/IFN-γ,rBHV-IL-2/IL-4,rBHV-GM-CSF,rBHV-HDAF,and rBHV-IRP1).This review outlines the status of research on BHV-1-based vaccines.

关 键 词：牛疱疹病毒I型 病毒 细胞因子 疫苗 综述 

分 类 号：R373.9[医药卫生—病原生物学]