血-视网膜屏障上腺嘌呤核苷三磷酸结合盒外排转运体的研究进展  

Research Progress of ATP-Binding Cassette Efflux Transporters on Blood-Retina Barrier

作　　者：金梦梦 刘李[1] 刘晓东[1] JIN Mengmeng;LIU Li;LIU Xiaodong(School of Pharmacy&Center of Drug Metabolism and Pharmacokinetics,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院药物代谢研究中心,江苏南京211198

出　　处：《药学进展》2021年第5期393-400,共8页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金项目(No.82073922,No.81872930,No.81673505);江苏省“333工程”(No.BRA2020287)。

摘　　要：血-视网膜屏障(BRB)是眼部重要的生物学屏障,能够调节血液和视网膜组织之间的物质交换,防止大分子和其他潜在的有害物质进入视网膜,维持视网膜微环境的稳定。BRB上表达多种外排及摄取转运体,在一些必需营养物质的摄取和神经递质代谢物、激素和药物的外排转运中发挥关键作用。通过对BRB的功能、相关外排转运体的表达和分布以及疾病状态下外排转运体的改变进行综述,以期为治疗视网膜疾病和维持视网膜功能健康的新药研发提供重要信息。As an important biological barrier of the eyes,blood-retina barrier(BRB)can regulate the material exchange between blood and retinal tissue,prevent macromolecules and other potentially harmful substances from entering the retina,and maintain the stability of the retinal microenvironment.It can express a variety of efflux and uptake transporters,which play a key role in the uptake of some essential nutrients and the efflux of neurotransmitter metabolites,hormones and drugs.This paper describes the function of BRB,the expression and distribution of related efflux transporters,and the changes of efflux transporters in disease states,providing important information for the development of new drugs for the treatment of retinal diseases and the maintenance of retinal functional health.

关 键 词：血-视网膜屏障 外排转运体 糖尿病 年龄相关性黄斑病变 

分 类 号：R969.1[医药卫生—药理学]