2018年南宁市0~59岁健康人群乙型肝炎血清流行病学调查  

Sero-epidemiological survey of hepatitis B in healthy population aged 0-59 years old in Nanning in 2018

作　　者：黄文胜[1] 唐金芳[1] 梁灵芝[1] 农初师[1] 甘文烨[1] 黄昌[1] 尹刘江[1] HUANG Wen-sheng;TANG Jin-fang;LIANG Ling-zhi;NONG Chu-shi;GAN Wen-ye;HUANG Chang;YIN Liu-jiang(Nanning Center for Disease Control and Prevention,Nanning,Guangxi 530028,China)

机构地区：[1]南宁市疾病预防控制中心,广西530028

出　　处：《应用预防医学》2021年第3期193-196,共4页Applied Preventive Medicine

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(Z20201384)。

摘　　要：目的了解南宁市0-59岁健康人群乙型肝炎(乙肝)免疫状况,为制定乙型肝炎防控策略提供科学依据。方法在南宁市抽取8个县(区),对0-59岁健康人群进行问卷调查及采集静脉血,检测乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)情况。结果南宁市0-59岁健康人群HBsAg、HBsAb阳性率分别为4.46%、70.56%。男性HBsAg阳性率为4.59%,女性HBsAg阳性率为4.33%,男女性HBsAg阳性率差异无统计学意义(χ^(2)=0.032,P=0.857);男性HBsAb阳性率为72.07%,女性HBsAb阳性率为69.25%,男、女性HBsAb阳性率间差异无统计学意义(χ^(2)=1.686,P=0.194)。0-14岁人群HBsAg阳性率为0.68%,低于15岁及以上人群HBsAg阳性率(9.60%)(χ^(2)=34.776,P<0.001)。15岁以下人群HBsAb阳性率随年龄增长而下降,0-1岁组HBsAb阳性率最高,为89.74%,10-14岁组最低,为52.49%(趋势χ^(2)=72.172,P<0.001)。城市居民HBsAb阳性率(78.77%)高于农村居民(63.65%)(χ^(2)=48.730,P<0.001)。完成乙肝全程接种的人群HBsAb阳性率(74.30%)明显高于未接种乙肝疫苗的人群阳性率(54.47%)(χ^(2)=21.136,P<0.001)。结论南宁市实施国家乙肝疫苗免疫策略成效显著,极大地保护了儿童的身体健康,5岁以下儿童乙肝防控是重点,要重视HBsAg阳性母亲的新生儿接种工作,同时重点关注农村地区乙肝防控。Objective To investigate the hepatitis B immune status among the healthy population aged between 0 and 59 years old in Nanning, and to provide scientific basis for formulating hepatitis B prevention and control strategy. Methods Hepatitis B surface antigen(HBsAg) and hepatitis B surface antibody(HBsAb) were detected for healthy people aged from 0 to 59 years old in 8 counties(districts) of Nanning by conducting questionnaire survey and collecting venous blood. Results The positive rates of HBsAg and HBsAb were 4.46% and 70.56%, respectively, among healthy people aged between 0 and 59 years old in Nanning. The positive rate of HBsAg was 4.59% in males and 4.33% in females, and there was no significant difference between male and female HBsAg positive rates(χ^(2)=0.032, P=0.857). The positive rate of HBsAb was 72.07% in males and 69.24% in females, and there was no significant difference between male and female HBs Ab positive rates(χ^(2)=1.686, P=0.194). The positive rate of HBs Ag in people aged between 0 and 14 years old was 0.68%, which was significantly lower than people aged 15 years old and over who had a positive HBs Ag rate of 9.60%(χ^(2)=34.776, P<0.001). The positive rate of HBs Ab decreased with the increase of age. The highest positive rate of HBs Ab was 89.74% in 0-1 year old group, and the lowest rate was 52.49% in 10-14 years old group(trend χ^(2)=72.172, P<0.001). The positive rate of HBs Ab among the urban population(78.77%) was higher than the rural population(63.65%)(χ^(2)=48.730, P<0.001). The positive rate of HBs Ab was 74.30% among people who completed the whole course of hepatitis B vaccination, which was significantly higher than the non-vaccinated population of 54.47%(χ^(2)=21.136, P<0.001). Conclusion The implementation of the national hepatitis B vaccination strategy in Nanning has achieved remarkable results, and it has greatly protected the health of children. The prevention and control of hepatitis B among people under the age of 5 is a key point, and attention should be paid to

关 键 词：乙型肝炎 抗原 抗体 免疫 

分 类 号：R512.6-3[医药卫生—内科学]