石家庄市非高碘地区8~10岁学龄儿童甲状腺肿大影响因素分析  

Analysis of influencing factors of goiter in school-age children aged 8 to 10 in non-high iodine areas of Shijiazhuang City

作　　者：牟振国 马志辉[2] 刘宪君 李卫红[2] 张海红[2] 薛伟华 Mu Zhenguo;Ma Zhihui;Liu Xianjun;Li Weihong;Zhang Haihong;Xue Weihua(Enforcement Office 2,Shijiazhuang Market Supervision and Administration Bureau,Shijiazhuang 050000,China;Institute for Endemic Disease Prevention and Control,Shijiazhuang Center for Disease Control and Prevention,Shijiazhuang 050011,China;Institute for Endemic Disease Prevention and Control,Pingshan Center for Disease Control and Prevention,Pingshan 050400,China)

机构地区：[1]石家庄市市场监督管理局执法二处,050000 [2]石家庄市疾病预防控制中心地方病防治所,050011 [3]平山县疾病预防控制中心地方病防治所,河北平山050400

出　　处：《中华地方病学杂志》2021年第7期558-562,共5页Chinese Journal of Endemiology

摘　　要：目的探讨石家庄市非高碘地区8~10岁学龄儿童甲状腺肿大的影响因素。方法2018年4月,在石家庄市选取9个非高碘县(市)作为监测点,采用容量比例概率抽样(PPS)法,每个监测点按东、西、南、北、中5个方位划分5个片区,每个片区抽取1个乡(镇),每个乡(镇)抽取1所小学,每所小学抽取40名8~10岁学龄儿童(年龄均衡、男女各半)作为调查对象。采集儿童任意1次尿样和生活饮用水水样,采用砷铈催化分光光度法检测尿碘和水碘含量;采用B超法测量儿童甲状腺容积;同时,测量儿童身高、体重,计算体质指数。采用logistic回归分析进行甲状腺肿大影响因素分析。结果共采集学龄儿童尿样1867份,尿碘中位数为190.65μg/L,处于碘适宜水平。共采集生活饮用水水样1046份,水碘范围为0.11~87.91μg/L,水碘中位数为3.01μg/L。共检测1867名学龄儿童甲状腺,甲状腺容积中位数为3.01 ml。男、女童(928、939例)甲状腺容积中位数分别为2.90、3.13 ml,不同性别间比较差异有统计学意义(U=2.09,P<0.05);8、9、10岁儿童(622、629、616例)甲状腺容积中位数分别为2.47、2.87、3.13 ml,不同年龄间比较差异有统计学意义(H=203.96,P<0.01);正常、超重、肥胖儿童(1231、300、336例)甲状腺容积中位数分别为2.61、3.05、3.16 ml,不同体质指数间比较差异有统计学意义(H=65.55,P<0.01)。多因素logistic回归分析结果显示,女性、肥胖是学龄儿童甲状腺肿大的危险因素[比值比(OR)=2.08、2.86,95%置信区间(CI):1.05~4.12、1.39~5.88,P均<0.05]。结论女性、肥胖是石家庄市非高碘地区8~10岁学龄儿童甲状腺肿大的危险因素。Objective To investigate the influencing factors of goiter in school-age children aged 8 to 10 in non-high iodine areas of Shijiazhuang City.Methods In April 2018,9 non-high iodine counties(cities)were selected as monitoring sites in Shijiazhuang City,and capacity proportional probability sampling(PPS)method was used.Each monitoring site was divided into five sampling areas according to five orientations:east,west,south,north,and middle,one township was selected from each area,one elementary school was selected from each township,and 40 school-age children aged 8 to 10(balanced age,half males and half females)were selected from each school as respondents.Urine samples from any one time of children and drinking water samples from their village were collected,and urinary iodine and water iodine were detected by arsenic cerium catalytic spectrophotometry;the thyroid volume of children was measured by B ultrasound method;at the same time,the height and weight of children were measured and the body mass index was calculated.The influencing factors of goiter were analyzed by logistic regression analysis.Results A total of 1867 urine samples of school-age children were collected,and the median urinary iodine was 190.65μg/L,which was in the suitable level of iodine.A total of 1046 drinking water samples were collected,water iodine ranged from 0.11 to 87.91μg/L,and the median water iodine was 3.01μg/L.A total of 1867 school-age children were tested thyroid,the median thyroid volume was 3.01 ml.The medians thyroid volume of boys and girls(928 and 939 cases)were 2.90 and 3.13 ml,respectively,the difference was statistically significant between sex(U=2.09,P<0.05);the medians thyroid volume of children aged 8,9,and 10 years old(622,629,616 cases)were 2.47,2.87,and 3.13 ml,respectively,the differences were statistically significant among ages(H=203.96,P<0.01);the medians thyroid volume of normal,overweight and obese children(1231,300,336 cases)were 2.61,3.05 and 3.16 ml,respectively,the differences were statistically signif

关 键 词：碘 儿童 甲状腺肿 影响因素 

分 类 号：R725.8[医药卫生—儿科]