微重力对骨稳态调节作用的相关研究进展  

Impact of microgravity on bone homeostasis

作　　者：段劭 李超[1] 林源[1] 陶树清[1] DUAN Shao;LI Chao;LIN Yuan;TAO Shu-qing(Department of Orthopedic Surgery,The Second Affiliated Hospital,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院骨外二科,黑龙江哈尔滨150081

出　　处：《中国矫形外科杂志》2021年第13期1209-1212,共4页Orthopedic Journal of China

基　　金：国家自然科学基金面上项目(编号:81873093)。

摘　　要：骨稳态的维持需要破骨细胞、成骨细胞和骨细胞的信号传导以及干细胞的增殖分化参与。微重力导致机械载荷减少进而改变骨稳态内细胞代谢。本综述介绍微重力对骨稳态的调节关系,以及其作用机制。微重力使成骨细胞增殖分化延迟,破骨细胞吸收增强,骨细胞溶解,巨噬细胞介导免疫炎症因子调控成骨和破骨平衡。骨骼系统的调节机制复杂,各细胞类型相互影响,多信号通路交叉作用。未来还需进一步探索骨稳态失调引起的骨质疏松的治疗靶点。Bone homeostasis is maintained by signal transduction among osteoblasts, osteoclasts and osteocytes, involving proliferation and differentiation of stem cells. Microgravity reduces the mechanical load that will change metabolism of bone cells in bone homeostasis.In this review the relations between microgravity and bone homeostasis and its mechanism will be introduced. In environment of microgravity, osteoblast histogenesis is delayed, osteoclasts absorption is enhanced with osteocyte osteolysis, which is related to macrophages mediated immune inflammation factor to regulate osteogenesis and bone resorption. Due to complexity of regulation mechanism for the skeletal system, multiple-type cells interact with each other by cross-action of multi-signal pathways. In the further, it needs to explore the therapeutic targets of osteoporosis induced by dysregulation of bone homeostasis.

关 键 词：微重力 骨稳态 成骨细胞 破骨细胞 骨细胞 巨噬细胞 

分 类 号：R687[医药卫生—骨科学]